Tofacitinib therapy for severe pyoderma gangrenosum in a patient with enteropathic arthritis : a case-based review
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is associated with systemic inflammatory conditions. Currently, there is no universally accepted standard therapy for PG, but immunosuppressive (IS) treatment seems essential. We report a patient here who was successfully treated with tofacitinib despite being PG-refractory to multiple anti-tumor necrosis factor alpha (anti-TNF) therapies and conventional IS. In addition, we performed a comprehensive review of all cases of PG treated with JAK inhibitors. We identified 27 cases treated with JAK inhibitors. Approximately 80% of the patients achieved complete recovery within a median of 12 weeks, even though 17 patients (63%) had received biologics before JAKinib treatment. Notably, this recovery could appear as early as 2 weeks. JAK inhibitors may prove useful in the future, particularly for treating immunosuppressive and steroid-resistant pyoderma gangrenosum, according to recent case reports.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
---|---|
Enthalten in: |
Rheumatology international - (2024) vom: 15. März |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Köken Avşar, Aydan [VerfasserIn] |
---|
Links: |
---|
Themen: |
Case report |
---|
Anmerkungen: |
Date Revised 15.03.2024 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.1007/s00296-024-05560-1 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369785495 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM369785495 | ||
003 | DE-627 | ||
005 | 20240316233208.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240316s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00296-024-05560-1 |2 doi | |
028 | 5 | 2 | |a pubmed24n1332.xml |
035 | |a (DE-627)NLM369785495 | ||
035 | |a (NLM)38488863 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Köken Avşar, Aydan |e verfasserin |4 aut | |
245 | 1 | 0 | |a Tofacitinib therapy for severe pyoderma gangrenosum in a patient with enteropathic arthritis |b a case-based review |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 15.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
520 | |a Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is associated with systemic inflammatory conditions. Currently, there is no universally accepted standard therapy for PG, but immunosuppressive (IS) treatment seems essential. We report a patient here who was successfully treated with tofacitinib despite being PG-refractory to multiple anti-tumor necrosis factor alpha (anti-TNF) therapies and conventional IS. In addition, we performed a comprehensive review of all cases of PG treated with JAK inhibitors. We identified 27 cases treated with JAK inhibitors. Approximately 80% of the patients achieved complete recovery within a median of 12 weeks, even though 17 patients (63%) had received biologics before JAKinib treatment. Notably, this recovery could appear as early as 2 weeks. JAK inhibitors may prove useful in the future, particularly for treating immunosuppressive and steroid-resistant pyoderma gangrenosum, according to recent case reports | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Case report | |
650 | 4 | |a Jak inhibitors | |
650 | 4 | |a Pyoderma gangrenosum | |
650 | 4 | |a Tofacitinib | |
700 | 1 | |a Demirci Yıldırım, Tuba |e verfasserin |4 aut | |
700 | 1 | |a Sarı, İsmail |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Rheumatology international |d 1985 |g (2024) vom: 15. März |w (DE-627)NLM012644315 |x 1437-160X |7 nnns |
773 | 1 | 8 | |g year:2024 |g day:15 |g month:03 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00296-024-05560-1 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2024 |b 15 |c 03 |