Impact of COVID-19 on posttraumatic stress disorder in ICU survivors : a prospective observational comparative cohort study
© 2024. The Author(s)..
BACKGROUND: Posttraumatic stress disorder (PTSD) after a stay in the intensive care unit (ICU) can affect one in five ICU survivors. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, admission to the ICU for COVID-19 was stressful due to the severity of this disease. This study assessed whether admission to the ICU for COVID-19 was associated with a higher prevalence of PTSD compared with other causes of ICU admission after adjustment for pre-ICU psychological factors.
METHODS: This prospective observational comparative cohort study included 31 ICUs. Eligible patients were adult ICU survivors hospitalized during the first wave of COVID-19 pandemic in France, regardless of the reason for admission. The prevalence of presumptive diagnosis of PTSD at 6 months was assessed using the PTSD Checklist for DSM-5 (PCL-5). Sociodemographics, clinical data, history of childhood trauma (Childhood Trauma Questionnaire [CTQ]), and exposure to potentially traumatic events (Life Events Checklist for DSM-5 [LEC-5]) were assessed.
RESULTS: Of the 778 ICU survivors included during the first wave of COVID-19 pandemic in France, 417 and 361 were assigned to the COVID-19 and non-COVID-19 cohorts, respectively. Fourteen (4.9%) and 11 (4.9%), respectively, presented with presumptive diagnosis of PTSD at 6 months (p = 0.976). After adjusting for age, sex, severity score at admission, use of invasive mechanical ventilation, ICU duration, CTQ and LEC-5, COVID-19 status was not associated with presumptive diagnosis of PTSD using the PCL-5. Only female sex was associated with presumptive diagnosis of PTSD. However, COVID-19 patients reported significantly more intrusion and avoidance symptoms than non-COVID patients (39% vs. 29%, p = 0.015 and 27% vs. 19%, p = 0.030), respectively. The median PCL-5 score was higher in the COVID-19 than non-COVID-19 cohort (9 [3, 20] vs. 4 [2, 16], p = 0.034).
CONCLUSION: Admission to the ICU for COVID-19 was not associated with a higher prevalence of PTSD compared with admission for another cause during the first wave of the COVID-19 pandemic in France. However, intrusion and avoidance symptoms were more frequent in COVID-19 patients than in non-COVID-19 patients.
TRIAL REGISTRATION: Clinicaltrials.gov Identifier NCT03991611, registered on June 19, 2019.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Critical care (London, England) - 28(2024), 1 vom: 14. März, Seite 77 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kalfon, Pierre [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COVID-19 |
|---|
| Anmerkungen: |
Date Completed 18.03.2024 Date Revised 05.04.2024 published: Electronic ClinicalTrials.gov: NCT03991611 Citation Status MEDLINE |
|---|
| doi: |
10.1186/s13054-024-04826-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369759915 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369759915 | ||
| 003 | DE-627 | ||
| 005 | 20240405233832.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240315s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13054-024-04826-1 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1366.xml |
| 035 | |a (DE-627)NLM369759915 | ||
| 035 | |a (NLM)38486304 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kalfon, Pierre |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of COVID-19 on posttraumatic stress disorder in ICU survivors |b a prospective observational comparative cohort study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.03.2024 | ||
| 500 | |a Date Revised 05.04.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT03991611 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND: Posttraumatic stress disorder (PTSD) after a stay in the intensive care unit (ICU) can affect one in five ICU survivors. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, admission to the ICU for COVID-19 was stressful due to the severity of this disease. This study assessed whether admission to the ICU for COVID-19 was associated with a higher prevalence of PTSD compared with other causes of ICU admission after adjustment for pre-ICU psychological factors | ||
| 520 | |a METHODS: This prospective observational comparative cohort study included 31 ICUs. Eligible patients were adult ICU survivors hospitalized during the first wave of COVID-19 pandemic in France, regardless of the reason for admission. The prevalence of presumptive diagnosis of PTSD at 6 months was assessed using the PTSD Checklist for DSM-5 (PCL-5). Sociodemographics, clinical data, history of childhood trauma (Childhood Trauma Questionnaire [CTQ]), and exposure to potentially traumatic events (Life Events Checklist for DSM-5 [LEC-5]) were assessed | ||
| 520 | |a RESULTS: Of the 778 ICU survivors included during the first wave of COVID-19 pandemic in France, 417 and 361 were assigned to the COVID-19 and non-COVID-19 cohorts, respectively. Fourteen (4.9%) and 11 (4.9%), respectively, presented with presumptive diagnosis of PTSD at 6 months (p = 0.976). After adjusting for age, sex, severity score at admission, use of invasive mechanical ventilation, ICU duration, CTQ and LEC-5, COVID-19 status was not associated with presumptive diagnosis of PTSD using the PCL-5. Only female sex was associated with presumptive diagnosis of PTSD. However, COVID-19 patients reported significantly more intrusion and avoidance symptoms than non-COVID patients (39% vs. 29%, p = 0.015 and 27% vs. 19%, p = 0.030), respectively. The median PCL-5 score was higher in the COVID-19 than non-COVID-19 cohort (9 [3, 20] vs. 4 [2, 16], p = 0.034) | ||
| 520 | |a CONCLUSION: Admission to the ICU for COVID-19 was not associated with a higher prevalence of PTSD compared with admission for another cause during the first wave of the COVID-19 pandemic in France. However, intrusion and avoidance symptoms were more frequent in COVID-19 patients than in non-COVID-19 patients | ||
| 520 | |a TRIAL REGISTRATION: Clinicaltrials.gov Identifier NCT03991611, registered on June 19, 2019 | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Critical care | |
| 650 | 4 | |a Intensive care unit | |
| 650 | 4 | |a Posttraumatic stress disorder | |
| 700 | 1 | |a El-Hage, Wissam |e verfasserin |4 aut | |
| 700 | 1 | |a Geantot, Marie-Agnès |e verfasserin |4 aut | |
| 700 | 1 | |a Favier, Constance |e verfasserin |4 aut | |
| 700 | 1 | |a Bodet-Contentin, Laetitia |e verfasserin |4 aut | |
| 700 | 1 | |a Kuteifan, Khaldoun |e verfasserin |4 aut | |
| 700 | 1 | |a Olivier, Pierre-Yves |e verfasserin |4 aut | |
| 700 | 1 | |a Thévenin, Didier |e verfasserin |4 aut | |
| 700 | 1 | |a Pottecher, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Crozon-Clauzel, Jullien |e verfasserin |4 aut | |
| 700 | 1 | |a Mauchien, Bénédicte |e verfasserin |4 aut | |
| 700 | 1 | |a Galbois, Arnaud |e verfasserin |4 aut | |
| 700 | 1 | |a de Varax, Roland |e verfasserin |4 aut | |
| 700 | 1 | |a Valera, Sabine |e verfasserin |4 aut | |
| 700 | 1 | |a Estagnasie, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Berric, Audrey |e verfasserin |4 aut | |
| 700 | 1 | |a Nyunga, Martine |e verfasserin |4 aut | |
| 700 | 1 | |a Revel, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Simon, Georges |e verfasserin |4 aut | |
| 700 | 1 | |a Kowalski, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Sossou, Achille |e verfasserin |4 aut | |
| 700 | 1 | |a Signouret, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Leone, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Delalé, Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Seemann, Aurélien |e verfasserin |4 aut | |
| 700 | 1 | |a Lasocki, Sigismond |e verfasserin |4 aut | |
| 700 | 1 | |a Quenot, Jean-Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Monsel, Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Michel, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Page, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a Patrigeon, René-Gilles |e verfasserin |4 aut | |
| 700 | 1 | |a Nicola, Walid |e verfasserin |4 aut | |
| 700 | 1 | |a Thille, Arnaud W |e verfasserin |4 aut | |
| 700 | 1 | |a Hekimian, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Auquier, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Baumstarck, Karine |e verfasserin |4 aut | |
| 700 | 0 | |a PTSD-REA Study group |e verfasserin |4 aut | |
| 700 | 1 | |a Catry, Hortense |e investigator |4 oth | |
| 700 | 1 | |a Dubus, Anne-Laure |e investigator |4 oth | |
| 700 | 1 | |a Laugery, Léa |e investigator |4 oth | |
| 700 | 1 | |a Lintaff, Marion |e investigator |4 oth | |
| 700 | 1 | |a Lourseyre, Mélanie |e investigator |4 oth | |
| 700 | 1 | |a Merigard, Lou |e investigator |4 oth | |
| 700 | 1 | |a Michel, Lisa |e investigator |4 oth | |
| 700 | 1 | |a Ouhmad, Nawal |e investigator |4 oth | |
| 700 | 1 | |a Petit, Solenn |e investigator |4 oth | |
| 700 | 1 | |a Tricoche, Laurence |e investigator |4 oth | |
| 700 | 1 | |a Beaumale, Florent |e investigator |4 oth | |
| 700 | 1 | |a Scholastique, Anne-Sylvie |e investigator |4 oth | |
| 700 | 1 | |a Mougenot, Emmanuelle |e investigator |4 oth | |
| 700 | 1 | |a Delerue, Céline |e investigator |4 oth | |
| 700 | 1 | |a Feller, Marc |e investigator |4 oth | |
| 700 | 1 | |a Grouille, Julien |e investigator |4 oth | |
| 700 | 1 | |a Rochon, Charles-Edouard |e investigator |4 oth | |
| 700 | 1 | |a Audibert, Juliette |e investigator |4 oth | |
| 700 | 1 | |a Badre, Gaëtan |e investigator |4 oth | |
| 700 | 1 | |a Jourdain, Cécile |e investigator |4 oth | |
| 700 | 1 | |a Lehaie, Leslie |e investigator |4 oth | |
| 700 | 1 | |a Abdelkader, Hasni Si |e investigator |4 oth | |
| 700 | 1 | |a Henry, Emilie |e investigator |4 oth | |
| 700 | 1 | |a Labruyere, Marie |e investigator |4 oth | |
| 700 | 1 | |a Boulle-Geronimi, Claire |e investigator |4 oth | |
| 700 | 1 | |a Beaussard, Stéphanie |e investigator |4 oth | |
| 700 | 1 | |a Nigeon, Olivier |e investigator |4 oth | |
| 700 | 1 | |a Loiez, Anthea |e investigator |4 oth | |
| 700 | 1 | |a Cerro, Valérie |e investigator |4 oth | |
| 700 | 1 | |a Marchand, Laetitia |e investigator |4 oth | |
| 700 | 1 | |a Arbelot, Charlotte |e investigator |4 oth | |
| 700 | 1 | |a Buzelier, Karine |e investigator |4 oth | |
| 700 | 1 | |a Levy, Deborah |e investigator |4 oth | |
| 700 | 1 | |a Leloup, Pascale |e investigator |4 oth | |
| 700 | 1 | |a Messaoudi, Karim |e investigator |4 oth | |
| 700 | 1 | |a Alzina, Camille |e investigator |4 oth | |
| 700 | 1 | |a Nguyen, Lee |e investigator |4 oth | |
| 700 | 1 | |a Nowak, Steve |e investigator |4 oth | |
| 700 | 1 | |a Ichai, Carole |e investigator |4 oth | |
| 700 | 1 | |a Diop, Aminata |e investigator |4 oth | |
| 700 | 1 | |a Brisson, Hélène |e investigator |4 oth | |
| 700 | 1 | |a Constantin, Jean-Michel |e investigator |4 oth | |
| 700 | 1 | |a Lakhal, Samia |e investigator |4 oth | |
| 700 | 1 | |a Oudihat, Madjid |e investigator |4 oth | |
| 700 | 1 | |a Coudroy, Rémi |e investigator |4 oth | |
| 700 | 1 | |a Guyon, Carole |e investigator |4 oth | |
| 700 | 1 | |a Frat, Jean-Pierre |e investigator |4 oth | |
| 700 | 1 | |a Robert, René |e investigator |4 oth | |
| 700 | 1 | |a Lubango, Nadine |e investigator |4 oth | |
| 700 | 1 | |a Villequey, Lisa |e investigator |4 oth | |
| 700 | 1 | |a Hecketsweiler, Stéphane |e investigator |4 oth | |
| 700 | 1 | |a Partouche, Nicolas |e investigator |4 oth | |
| 700 | 1 | |a Ducros, Laurent |e investigator |4 oth | |
| 700 | 1 | |a Gardan, Vincent |e investigator |4 oth | |
| 700 | 1 | |a Rivoire, Julie |e investigator |4 oth | |
| 700 | 1 | |a Deparis-Dusautois, Stéphanie |e investigator |4 oth | |
| 700 | 1 | |a Lamri, Lamia |e investigator |4 oth | |
| 700 | 1 | |a Lavalart, Alexandra |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Critical care (London, England) |d 1997 |g 28(2024), 1 vom: 14. März, Seite 77 |w (DE-627)NLM097399787 |x 1466-609X |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2024 |g number:1 |g day:14 |g month:03 |g pages:77 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s13054-024-04826-1 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2024 |e 1 |b 14 |c 03 |h 77 | ||