Senolytics prevent age-associated changes in female mice brain
Copyright © 2024 Elsevier B.V. All rights reserved..
PURPOSE: Considering that the combination of dasatinib and quercetin (D + Q) demonstrated a neuroprotective action, as well as that females experience a decline in hormonal levels during aging and this is linked to increased susceptibility to Alzheimer's disease, in this study we evaluated the effect of D + Q on inflammatory and oxidative stress markers and on acetylcholinesterase and Na+, K+-ATPase activities in brain of female mice.
METHODS: Female C57BL/6 mice were divided in Control and D (5 mg/kg) + Q (50 mg/kg) treated. Treatment was administered via gavage for three consecutive days every two weeks starting at 30 days of age. The animals were euthanized at 6 months of age and at 14 months of age.
RESULTS: Results indicate an increase in reactive species (RS), thiol content and lipid peroxidation followed by a reduction in nitrite levels and superoxide dismutase, catalase and glutathione S-transferase activity in the brain of control animals with age. D+Q protected against age-associated increase in RS and catalase activity reduction. Acetylcholinesterase activity was increased, while Na+, K+-ATPase activity was reduced at 14 months of age and D+Q prevented this reduction.
CONCLUSION: These data demonstrate that D+Q can protect against age-associated neurochemical alterations in the female brain.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:826 |
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| Enthalten in: |
Neuroscience letters - 826(2024) vom: 15. März, Seite 137730 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Faria, Olivia Wyse [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 01.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2024.137730 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369747666 |
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| 100 | 1 | |a Faria, Olivia Wyse |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Senolytics prevent age-associated changes in female mice brain |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 01.04.2024 | ||
| 500 | |a Date Revised 01.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a PURPOSE: Considering that the combination of dasatinib and quercetin (D + Q) demonstrated a neuroprotective action, as well as that females experience a decline in hormonal levels during aging and this is linked to increased susceptibility to Alzheimer's disease, in this study we evaluated the effect of D + Q on inflammatory and oxidative stress markers and on acetylcholinesterase and Na+, K+-ATPase activities in brain of female mice | ||
| 520 | |a METHODS: Female C57BL/6 mice were divided in Control and D (5 mg/kg) + Q (50 mg/kg) treated. Treatment was administered via gavage for three consecutive days every two weeks starting at 30 days of age. The animals were euthanized at 6 months of age and at 14 months of age | ||
| 520 | |a RESULTS: Results indicate an increase in reactive species (RS), thiol content and lipid peroxidation followed by a reduction in nitrite levels and superoxide dismutase, catalase and glutathione S-transferase activity in the brain of control animals with age. D+Q protected against age-associated increase in RS and catalase activity reduction. Acetylcholinesterase activity was increased, while Na+, K+-ATPase activity was reduced at 14 months of age and D+Q prevented this reduction | ||
| 520 | |a CONCLUSION: These data demonstrate that D+Q can protect against age-associated neurochemical alterations in the female brain | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acetylcholinesterase | |
| 650 | 4 | |a Brain | |
| 650 | 4 | |a Dasatinib | |
| 650 | 4 | |a Na(+), K(+)-ATPase | |
| 650 | 4 | |a Quercetin | |
| 650 | 4 | |a Redox status | |
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| 650 | 7 | |a Senotherapeutics |2 NLM | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Quercetin |2 NLM | |
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| 650 | 7 | |a Adenosine Triphosphatases |2 NLM | |
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| 700 | 1 | |a de Aguiar, Mayara Sandrielly Soares |e verfasserin |4 aut | |
| 700 | 1 | |a de Mello, Julia Eisenhardt |e verfasserin |4 aut | |
| 700 | 1 | |a Alvez, Fernando Lopez |e verfasserin |4 aut | |
| 700 | 1 | |a Luduvico, Karina Pereira |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia, Driele Neske |e verfasserin |4 aut | |
| 700 | 1 | |a Schneider, Augusto |e verfasserin |4 aut | |
| 700 | 1 | |a Masternak, Michal M |e verfasserin |4 aut | |
| 700 | 1 | |a Spanevello, Roselia Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Stefanello, Francieli Moro |e verfasserin |4 aut | |
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