A humoral stress response protects Drosophila tissues from antimicrobial peptides
Copyright © 2024 Elsevier Inc. All rights reserved..
7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress. Flies lacking Turandot genes are susceptible to environmental stresses due to AMP-induced tracheal apoptosis. Turandot proteins bind to host cell membranes and mask negatively charged phospholipids, protecting them from cationic pore-forming AMPs. Collectively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissues and therefore improve their efficacy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Current biology : CB - 34(2024), 7 vom: 08. Apr., Seite 1426-1437.e6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rommelaere, Samuel [VerfasserIn] |
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| Links: |
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| Themen: |
Antimicrobial Cationic Peptides |
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| Anmerkungen: |
Date Completed 11.04.2024 Date Revised 11.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cub.2024.02.049 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369744225 |
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| 520 | |a 7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress. Flies lacking Turandot genes are susceptible to environmental stresses due to AMP-induced tracheal apoptosis. Turandot proteins bind to host cell membranes and mask negatively charged phospholipids, protecting them from cationic pore-forming AMPs. Collectively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissues and therefore improve their efficacy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a antimicrobial peptides | |
| 650 | 4 | |a immunopathology | |
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| 650 | 4 | |a resilience | |
| 650 | 4 | |a stress response | |
| 650 | 4 | |a trachea | |
| 650 | 7 | |a Antimicrobial Peptides |2 NLM | |
| 650 | 7 | |a Antimicrobial Cationic Peptides |2 NLM | |
| 650 | 7 | |a Drosophila Proteins |2 NLM | |
| 700 | 1 | |a Carboni, Alexia |e verfasserin |4 aut | |
| 700 | 1 | |a Bada Juarez, Juan F |e verfasserin |4 aut | |
| 700 | 1 | |a Boquete, Jean-Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Abriata, Luciano A |e verfasserin |4 aut | |
| 700 | 1 | |a Teixeira Pinto Meireles, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Rukes, Verena |e verfasserin |4 aut | |
| 700 | 1 | |a Vincent, Crystal |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Shu |e verfasserin |4 aut | |
| 700 | 1 | |a Dionne, Marc S |e verfasserin |4 aut | |
| 700 | 1 | |a Dal Peraro, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Chan |e verfasserin |4 aut | |
| 700 | 1 | |a Lemaitre, Bruno |e verfasserin |4 aut | |
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