β-Carbonyl sulfonium enables cysteine-specific bioconjugation for activity-based protein profiling in live cells
Chemical labeling methods for proteins are highly researched. Herein, we introduced β-carbonyl sulfonium compounds for selective cysteine modification in proteins within biological systems. Structural tuning led to sulfonium-based probes with high reactivity and selectivity. These probes show excellent biocompatibility, cell uptake, and specificity towards cysteine profiling in live cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 60(2024), 27 vom: 28. März, Seite 3725-3728 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wan, Chuan [VerfasserIn] |
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| Links: |
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| Themen: |
Cysteine |
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| Anmerkungen: |
Date Completed 29.03.2024 Date Revised 29.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d4cc00295d |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Chemical labeling methods for proteins are highly researched. Herein, we introduced β-carbonyl sulfonium compounds for selective cysteine modification in proteins within biological systems. Structural tuning led to sulfonium-based probes with high reactivity and selectivity. These probes show excellent biocompatibility, cell uptake, and specificity towards cysteine profiling in live cells | ||
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| 700 | 1 | |a Yang, Dongyan |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Xiaochun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Tuanjie |e verfasserin |4 aut | |
| 700 | 1 | |a Ruan, Zhijun |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zigang |e verfasserin |4 aut | |
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