The exceptions that prove the rule-a historical view of bedaquiline susceptibility
© 2024. The Author(s)..
In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Genome medicine - 16(2024), 1 vom: 13. März, Seite 39 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Miotto, Paolo [VerfasserIn] |
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| Links: |
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| Themen: |
78846I289Y |
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| Anmerkungen: |
Date Completed 15.03.2024 Date Revised 15.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s13073-024-01311-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Köser, Claudio U |e verfasserin |4 aut | |
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