Elevated Plasma Lipoprotein(a) Level and Atherosclerotic Cardiovascular Disease Risks : A Large Clinical Retrospective Study
Patients with well-controlled low-density lipoprotein cholesterol (LDL-C) levels still suffer from the progress of the atherosclerotic cardiovascular disease (ASCVD) and can develop adverse outcomes. We conducted this study to analyze the relationship between elevated lipoprotein(a) [Lp(a)] levels and ASCVD risk. We enrolled 8070 patients in the ASCVD group and 440 participants in the non-ASCVD group [median age of 60 years; 6376 (74.9%) were male]. Multivariate logistic regression models were used to identify the relationships between the lipids and ASCVD. These models showed that the Lp(a) level was a significant independent risk factor for ASCVD [odds ratio (OR) = 1.025, confidence interval (CI) = 1.020-1.029, P < .001]. The different categories analysis showed the OR of the high Lp(a)/low LDL-C group was 9.612 [CI = 6.206-14.887], P < .001. Our study demonstrated that elevated Lp(a) levels were associated with the increased ASCVD risk. Also, the patients with low LDL-C but high Lp(a) levels still had a higher risk of developing ASCVD than the low Lp(a)/high LDL-C group. In addition, elevated Lp(a) levels were associated with a higher ASCVD risk in males, hypertensive, and diabetic patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Angiology - (2024) vom: 13. März, Seite 33197241239688 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Kexin [VerfasserIn] |
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| Links: |
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| Themen: |
Atherosclerotic cardiovascular disease |
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| Anmerkungen: |
Date Revised 13.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1177/00033197241239688 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369701712 |
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| 245 | 1 | 0 | |a Elevated Plasma Lipoprotein(a) Level and Atherosclerotic Cardiovascular Disease Risks |b A Large Clinical Retrospective Study |
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| 520 | |a Patients with well-controlled low-density lipoprotein cholesterol (LDL-C) levels still suffer from the progress of the atherosclerotic cardiovascular disease (ASCVD) and can develop adverse outcomes. We conducted this study to analyze the relationship between elevated lipoprotein(a) [Lp(a)] levels and ASCVD risk. We enrolled 8070 patients in the ASCVD group and 440 participants in the non-ASCVD group [median age of 60 years; 6376 (74.9%) were male]. Multivariate logistic regression models were used to identify the relationships between the lipids and ASCVD. These models showed that the Lp(a) level was a significant independent risk factor for ASCVD [odds ratio (OR) = 1.025, confidence interval (CI) = 1.020-1.029, P < .001]. The different categories analysis showed the OR of the high Lp(a)/low LDL-C group was 9.612 [CI = 6.206-14.887], P < .001. Our study demonstrated that elevated Lp(a) levels were associated with the increased ASCVD risk. Also, the patients with low LDL-C but high Lp(a) levels still had a higher risk of developing ASCVD than the low Lp(a)/high LDL-C group. In addition, elevated Lp(a) levels were associated with a higher ASCVD risk in males, hypertensive, and diabetic patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a atherosclerotic cardiovascular disease | |
| 650 | 4 | |a clinical retrospective study | |
| 650 | 4 | |a hyperlipidemia | |
| 650 | 4 | |a lipoprotein(a) | |
| 650 | 4 | |a risk factors | |
| 700 | 1 | |a Wang, Wenjie |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Jialong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Hongya |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Ge, Hailong |e verfasserin |4 aut | |
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