Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved..
To understand the dynamic interplay between the human microbiome and host during health and disease, we analyzed the microbial composition, temporal dynamics, and associations with host multi-omics, immune, and clinical markers of microbiomes from four body sites in 86 participants over 6 years. We found that microbiome stability and individuality are body-site specific and heavily influenced by the host. The stool and oral microbiome are more stable than the skin and nasal microbiomes, possibly due to their interaction with the host and environment. We identify individual-specific and commonly shared bacterial taxa, with individualized taxa showing greater stability. Interestingly, microbiome dynamics correlate across body sites, suggesting systemic dynamics influenced by host-microbial-environment interactions. Notably, insulin-resistant individuals show altered microbial stability and associations among microbiome, molecular markers, and clinical features, suggesting their disrupted interaction in metabolic disease. Our study offers comprehensive views of multi-site microbial dynamics and their relationship with host health and disease.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Cell host & microbe - 32(2024), 4 vom: 10. Apr., Seite 506-526.e9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhou, Xin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 25.04.2024 published: Print-Electronic UpdateOf: bioRxiv. 2024 Feb 01;:. - PMID 38352363 Citation Status MEDLINE |
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| doi: |
10.1016/j.chom.2024.02.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369691040 |
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| 500 | |a UpdateOf: bioRxiv. 2024 Feb 01;:. - PMID 38352363 | ||
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a To understand the dynamic interplay between the human microbiome and host during health and disease, we analyzed the microbial composition, temporal dynamics, and associations with host multi-omics, immune, and clinical markers of microbiomes from four body sites in 86 participants over 6 years. We found that microbiome stability and individuality are body-site specific and heavily influenced by the host. The stool and oral microbiome are more stable than the skin and nasal microbiomes, possibly due to their interaction with the host and environment. We identify individual-specific and commonly shared bacterial taxa, with individualized taxa showing greater stability. Interestingly, microbiome dynamics correlate across body sites, suggesting systemic dynamics influenced by host-microbial-environment interactions. Notably, insulin-resistant individuals show altered microbial stability and associations among microbiome, molecular markers, and clinical features, suggesting their disrupted interaction in metabolic disease. Our study offers comprehensive views of multi-site microbial dynamics and their relationship with host health and disease | ||
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| 700 | 1 | |a Spakowicz, Daniel J |e verfasserin |4 aut | |
| 700 | 1 | |a Agnello, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Wenyu |e verfasserin |4 aut | |
| 700 | 1 | |a Avina, Monica |e verfasserin |4 aut | |
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| 700 | 1 | |a Hong, Bo-Young |e verfasserin |4 aut | |
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