Role of tubulin C-terminal tail on mechanical properties of microtubule
Copyright © 2024 Elsevier Inc. All rights reserved..
Tubulin C-terminal tail (CTT) is a disordered segment extended from each tubulin monomer of αβ tubulin heterodimers, the building blocks of microtubules. The tubulin CTT contributes to the cellular function of microtubules such as intracellular transportation by regulating their interaction with other proteins and cell shape regulation by controlling microtubule polymerization dynamics. Although the mechanical integrity of microtubules is crucial for their functions, the role of tubulin CTT on microtubule mechanical properties has remained elusive. In this work, we investigate the role of tubulin CTTs in regulating the mechanical properties of microtubules by estimating the persistence lengths and investigating the buckling behavior of microtubules with and without CTT. We find that microtubules with intact CTTs exhibit twice the rigidity of microtubules lacking tubulin CTTs. Our study will widen the scope of altering microtubule mechanical properties for its application in nano bio-devices and lead to novel therapeutic approaches for neurodegenerative diseases with altered microtubule properties.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:706 |
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| Enthalten in: |
Biochemical and biophysical research communications - 706(2024) vom: 30. März, Seite 149761 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nowroz, Senjuti [VerfasserIn] |
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| Links: |
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| Themen: |
Bucklin |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbrc.2024.149761 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369689569 |
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| 520 | |a Copyright © 2024 Elsevier Inc. All rights reserved. | ||
| 520 | |a Tubulin C-terminal tail (CTT) is a disordered segment extended from each tubulin monomer of αβ tubulin heterodimers, the building blocks of microtubules. The tubulin CTT contributes to the cellular function of microtubules such as intracellular transportation by regulating their interaction with other proteins and cell shape regulation by controlling microtubule polymerization dynamics. Although the mechanical integrity of microtubules is crucial for their functions, the role of tubulin CTT on microtubule mechanical properties has remained elusive. In this work, we investigate the role of tubulin CTTs in regulating the mechanical properties of microtubules by estimating the persistence lengths and investigating the buckling behavior of microtubules with and without CTT. We find that microtubules with intact CTTs exhibit twice the rigidity of microtubules lacking tubulin CTTs. Our study will widen the scope of altering microtubule mechanical properties for its application in nano bio-devices and lead to novel therapeutic approaches for neurodegenerative diseases with altered microtubule properties | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bucklin | |
| 650 | 4 | |a C-terminal tail | |
| 650 | 4 | |a Mechanical properties | |
| 650 | 4 | |a Microtubule | |
| 650 | 4 | |a Persistence length | |
| 650 | 4 | |a Tubulin | |
| 650 | 7 | |a Tubulin |2 NLM | |
| 700 | 1 | |a Nasrin, Syeda Rubaiya |e verfasserin |4 aut | |
| 700 | 1 | |a Kabir, Arif Md Rashedul |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Takefumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kusumoto, Tomoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Taira, Junichi |e verfasserin |4 aut | |
| 700 | 1 | |a Tani, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Ichikawa, Masatoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Sada, Kazuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kakugo, Akira |e verfasserin |4 aut | |
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