Development, techniques, and utility of experimental animal models of thoracic and abdominal aortic aneurysms
Aneurysms are clinical entities that can develop and affect human aorta; and although in most cases they have an asymptomatic course, these pathological dilatations can lead to a lethal outcome when rupture occurs, thus the establishment of predictors is crucial for death prevention. Essential events that take place in the vessel wall have been identified and described, such as inflammation, proteolysis, smooth muscle cell apoptosis, angiogenesis, and vascular remodeling. Porcine and ovine models have been useful for the development and evaluation of endovascular devices of the aorta. However, since the worldwide introduction and adoption of these minimally invasive techniques for aneurysm repair, there is lesser availability of diseased aortic tissue for molecular, cellular, and histopathological analysis, therefore over the last three decades it has been proposed various small species models that have allowed the focal induction of these lesions for the study of physiopathological mechanisms and possible useful biomarkers as diagnostic and therapeutic targets. The present review article presents and discusses the animal models available as their applications, characteristics, advantages, and limitations for the development of preclinical studies, and their importance in the comprehension of this pathology in humans.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Archivos de cardiologia de Mexico - (2024) vom: 13. März |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Desarrollo, técnicas y utilidad de modelos animales experimentales de aneurismas aórticos torácicos y abdominales |
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| Beteiligte Personen: |
Bravo-Reyna, Carlos C [VerfasserIn] |
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| Links: |
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| Themen: |
Aortic aneurysms. Animals models. Extracellular matrix. Calcium chloride. Elastase. Angiotensin II. |
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| Anmerkungen: |
Date Revised 13.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.24875/ACM.23000180 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369687027 |
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| 245 | 1 | 0 | |a Development, techniques, and utility of experimental animal models of thoracic and abdominal aortic aneurysms |
| 246 | 3 | 3 | |a Desarrollo, técnicas y utilidad de modelos animales experimentales de aneurismas aórticos torácicos y abdominales |
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| 520 | |a Aneurysms are clinical entities that can develop and affect human aorta; and although in most cases they have an asymptomatic course, these pathological dilatations can lead to a lethal outcome when rupture occurs, thus the establishment of predictors is crucial for death prevention. Essential events that take place in the vessel wall have been identified and described, such as inflammation, proteolysis, smooth muscle cell apoptosis, angiogenesis, and vascular remodeling. Porcine and ovine models have been useful for the development and evaluation of endovascular devices of the aorta. However, since the worldwide introduction and adoption of these minimally invasive techniques for aneurysm repair, there is lesser availability of diseased aortic tissue for molecular, cellular, and histopathological analysis, therefore over the last three decades it has been proposed various small species models that have allowed the focal induction of these lesions for the study of physiopathological mechanisms and possible useful biomarkers as diagnostic and therapeutic targets. The present review article presents and discusses the animal models available as their applications, characteristics, advantages, and limitations for the development of preclinical studies, and their importance in the comprehension of this pathology in humans | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aortic aneurysms. Animals models. Extracellular matrix. Calcium chloride. Elastase. Angiotensin II. | |
| 700 | 1 | |a Mejía-Cervantes, Jacqueline |e verfasserin |4 aut | |
| 700 | 1 | |a Verduzco-Vázquez, Ana T |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Rodríguez, Cristopher |e verfasserin |4 aut | |
| 700 | 1 | |a Cuervo-Vargas, Leonardo |e verfasserin |4 aut | |
| 700 | 1 | |a Medina-Velázquez, Luis A |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez-Vergara, Víctor |e verfasserin |4 aut | |
| 700 | 1 | |a Hinojosa, Carlos A |e verfasserin |4 aut | |
| 700 | 1 | |a Anaya-Ayala, Javier E |e verfasserin |4 aut | |
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