Sedentary behavior does not predict low BMD nor fracture-population-based Canadian Multicentre Osteoporosis Study
© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research..
Sedentary behavior (SB) or sitting is associated with multiple unfavorable health outcomes. Bone tissue responds to imposed gravitational and muscular strain with there being some evidence suggesting a causal link between SB and poor bone health. However, there are no population-based data on the longitudinal relationship between SB, bone change, and incidence of fragility fractures. This study aimed to examine the associations of sitting/SB (defined as daily sitting time), areal BMD (by DXA), and incident low trauma (fragility) osteoporotic fractures (excluding hands, feet, face, and head). We measured baseline (1995-7) and 10-yr self-reported SB, femoral neck (FN), total hip (TH), and lumbar spine (L1-L4) BMD in 5708 women and 2564 men aged 25 to 80+ yr from the population-based, nationwide, 9-center Canadian Multicentre Osteoporosis Study. Incident 10-yr fragility fracture data were obtained from 4624 participants; >80% of fractures were objectively confirmed by medical records or radiology reports. Vertebral fractures were confirmed by qualitative morphological methods. All analyses were stratified by sex. Multivariable regression models assessed SB-BMD relationships; Cox proportional models were fit for fracture risk. Models were adjusted for age, height, BMI, physical activity, and sex-specific covariates. Women in third/fourth quartiles had lower adjusted FN BMD versus women with the least SB (first quartile); women in the SB third quartile had lower adjusted TH BMD. Men in the SB third quartile had lower adjusted FN BMD than those in SB first quartile. Neither baseline nor stable 10-yr SB was related to BMD change nor to incident fragility fractures. Increased sitting (SB) in this large, population-based cohort was associated with lower baseline FN BMD. Stable SB was not associated with 10-yr BMD loss nor increased fragility fracture. In conclusion, habitual adult SB was not associated with subsequent loss of BMD nor increased risk of fracture.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 39(2024), 3 vom: 19. Apr., Seite 231-240 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guðmundsdóttir, Sigríður Lára [VerfasserIn] |
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| Links: |
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| Themen: |
Areal BMD |
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| Anmerkungen: |
Date Completed 22.04.2024 Date Revised 22.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/jbmr/zjae004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Guðmundsdóttir, Sigríður Lára |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sedentary behavior does not predict low BMD nor fracture-population-based Canadian Multicentre Osteoporosis Study |
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| 520 | |a © The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. | ||
| 520 | |a Sedentary behavior (SB) or sitting is associated with multiple unfavorable health outcomes. Bone tissue responds to imposed gravitational and muscular strain with there being some evidence suggesting a causal link between SB and poor bone health. However, there are no population-based data on the longitudinal relationship between SB, bone change, and incidence of fragility fractures. This study aimed to examine the associations of sitting/SB (defined as daily sitting time), areal BMD (by DXA), and incident low trauma (fragility) osteoporotic fractures (excluding hands, feet, face, and head). We measured baseline (1995-7) and 10-yr self-reported SB, femoral neck (FN), total hip (TH), and lumbar spine (L1-L4) BMD in 5708 women and 2564 men aged 25 to 80+ yr from the population-based, nationwide, 9-center Canadian Multicentre Osteoporosis Study. Incident 10-yr fragility fracture data were obtained from 4624 participants; >80% of fractures were objectively confirmed by medical records or radiology reports. Vertebral fractures were confirmed by qualitative morphological methods. All analyses were stratified by sex. Multivariable regression models assessed SB-BMD relationships; Cox proportional models were fit for fracture risk. Models were adjusted for age, height, BMI, physical activity, and sex-specific covariates. Women in third/fourth quartiles had lower adjusted FN BMD versus women with the least SB (first quartile); women in the SB third quartile had lower adjusted TH BMD. Men in the SB third quartile had lower adjusted FN BMD than those in SB first quartile. Neither baseline nor stable 10-yr SB was related to BMD change nor to incident fragility fractures. Increased sitting (SB) in this large, population-based cohort was associated with lower baseline FN BMD. Stable SB was not associated with 10-yr BMD loss nor increased fragility fracture. In conclusion, habitual adult SB was not associated with subsequent loss of BMD nor increased risk of fracture | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CaMos | |
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| 650 | 4 | |a incident fragility fractures | |
| 650 | 4 | |a population-based cohort | |
| 650 | 4 | |a sedentary behavior | |
| 700 | 1 | |a Berger, Claudie |e verfasserin |4 aut | |
| 700 | 1 | |a Macdonald, Heather |e verfasserin |4 aut | |
| 700 | 1 | |a Adachi, Jonathan D |e verfasserin |4 aut | |
| 700 | 1 | |a Hopman, Wilma M |e verfasserin |4 aut | |
| 700 | 1 | |a Kaiser, Stephanie M |e verfasserin |4 aut | |
| 700 | 1 | |a Kovacs, Christopher S |e verfasserin |4 aut | |
| 700 | 1 | |a Davison, Kenneth Shawn |e verfasserin |4 aut | |
| 700 | 1 | |a Morin, Suzanne N |e verfasserin |4 aut | |
| 700 | 1 | |a Goltzman, David |e verfasserin |4 aut | |
| 700 | 0 | |a CaMos Research Group |e verfasserin |4 aut | |
| 700 | 1 | |a Prior, Jerilynn C |e verfasserin |4 aut | |
| 700 | 1 | |a Goltzman, David |e investigator |4 oth | |
| 700 | 1 | |a Kreiger, Nancy |e investigator |4 oth | |
| 700 | 1 | |a Tenenhouse, Alan |e investigator |4 oth | |
| 700 | 1 | |a Rahme, Elham |e investigator |4 oth | |
| 700 | 1 | |a Brent Richards, J |e investigator |4 oth | |
| 700 | 1 | |a Morin, Suzanne N |e investigator |4 oth | |
| 700 | 1 | |a Berger, Claudie |e investigator |4 oth | |
| 700 | 1 | |a Joyce, Carol |e investigator |4 oth | |
| 700 | 1 | |a Kovacs, Christopher S |e investigator |4 oth | |
| 700 | 1 | |a Kirkland, Susan |e investigator |4 oth | |
| 700 | 1 | |a Kaiser, Stephanie M |e investigator |4 oth | |
| 700 | 1 | |a Brown, Jacques P |e investigator |4 oth | |
| 700 | 1 | |a Bessette, Louis |e investigator |4 oth | |
| 700 | 1 | |a Anastassiades, Tassos P |e investigator |4 oth | |
| 700 | 1 | |a Towheed, Tanveer |e investigator |4 oth | |
| 700 | 1 | |a Hopman, Wilma M |e investigator |4 oth | |
| 700 | 1 | |a Cheung, Angela M |e investigator |4 oth | |
| 700 | 1 | |a Josse, Robert G |e investigator |4 oth | |
| 700 | 1 | |a Kin On Wong, Andy |e investigator |4 oth | |
| 700 | 1 | |a Adachi, Jonathan D |e investigator |4 oth | |
| 700 | 1 | |a Papaioannou, Alexandra |e investigator |4 oth | |
| 700 | 1 | |a Olszynski, Wojciech P |e investigator |4 oth | |
| 700 | 1 | |a Shawn Davison, K |e investigator |4 oth | |
| 700 | 1 | |a Hanley, David A |e investigator |4 oth | |
| 700 | 1 | |a Boyd, Steven K |e investigator |4 oth | |
| 700 | 1 | |a Prior, Jerilynn C |e investigator |4 oth | |
| 700 | 1 | |a Kalyan, Shirin |e investigator |4 oth | |
| 700 | 1 | |a Lentle, Brian |e investigator |4 oth | |
| 700 | 1 | |a Patel, Millan S |e investigator |4 oth | |
| 700 | 1 | |a Jackson, Stuart D |e investigator |4 oth | |
| 700 | 1 | |a Leslie, William D |e investigator |4 oth | |
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