Outcomes for patients undergoing transcatheter aortic valve replacement with ascending aorta dilation
Copyright © 2024 Elsevier B.V. All rights reserved..
BACKGROUND: We aim to compare the short and long-term outcomes for aortic stenosis (AS) patients undergone TAVR with and without ascending aorta dilation (AAD).
METHODS: Consecutive patients diagnosed with native severe AS who underwent TAVR from September 2012 to September 2021 were enrolled. They were stratified into the moderate/severe dilation group (greatest ascending aorta width ≥ 45 mm) and the non/mild dilation group. Survival outcomes were illustrated using Kaplan-Meier curves and evaluated with the log-rank test. Data from patients with CT follow-up of >6 months was used to investigate the progression rate of AAD.
RESULTS: The study cohort comprised 556 patients, with a mean age of 75.5 ± 7.3 years. Among them, 107 patients (19.2%) had a moderate/severe AAD (≥45 mm), with an average diameter of 48.6 mm (±2.8). During hospitalization, both groups witnessed two cases of ascending aortic dissection (1.9% vs 0.4%, P = 0.380). The median follow-up duration was 3.9 years (95% CI: 3.8-4.0 years). No deaths were caused by aortic events and no patients experienced a new aortic dissection. The AAD cohort's 4-year all-cause and cardiovascular mortality rates were not significantly different to the non/mild dilation group's (log-rank test, P = 0.109 and P = 0.698, respectively). Follow-up CT data revealed that the rate of aortic dilation progression in the moderate/severe dilation group was not significantly different from that in the non/mild group (0.0 mm/year, 25-75%th: -0.3-0.2 vs 0.1 mm/year, 25-75%th: -0.3-0.4, P = 0.122).
CONCLUSION: This study found no significant difference regarding short-term and long-term outcomes in AS patients with/without moderate/severe AAD undergoing TAVR.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:405 |
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| Enthalten in: |
International journal of cardiology - 405(2024) vom: 15. Apr., Seite 131948 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Feng, Dejing [VerfasserIn] |
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| Links: |
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| Themen: |
Aortic aneurysm |
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| Anmerkungen: |
Date Completed 26.04.2024 Date Revised 26.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2024.131948 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369613716 |
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| 100 | 1 | |a Feng, Dejing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Outcomes for patients undergoing transcatheter aortic valve replacement with ascending aorta dilation |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 26.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: We aim to compare the short and long-term outcomes for aortic stenosis (AS) patients undergone TAVR with and without ascending aorta dilation (AAD) | ||
| 520 | |a METHODS: Consecutive patients diagnosed with native severe AS who underwent TAVR from September 2012 to September 2021 were enrolled. They were stratified into the moderate/severe dilation group (greatest ascending aorta width ≥ 45 mm) and the non/mild dilation group. Survival outcomes were illustrated using Kaplan-Meier curves and evaluated with the log-rank test. Data from patients with CT follow-up of >6 months was used to investigate the progression rate of AAD | ||
| 520 | |a RESULTS: The study cohort comprised 556 patients, with a mean age of 75.5 ± 7.3 years. Among them, 107 patients (19.2%) had a moderate/severe AAD (≥45 mm), with an average diameter of 48.6 mm (±2.8). During hospitalization, both groups witnessed two cases of ascending aortic dissection (1.9% vs 0.4%, P = 0.380). The median follow-up duration was 3.9 years (95% CI: 3.8-4.0 years). No deaths were caused by aortic events and no patients experienced a new aortic dissection. The AAD cohort's 4-year all-cause and cardiovascular mortality rates were not significantly different to the non/mild dilation group's (log-rank test, P = 0.109 and P = 0.698, respectively). Follow-up CT data revealed that the rate of aortic dilation progression in the moderate/severe dilation group was not significantly different from that in the non/mild group (0.0 mm/year, 25-75%th: -0.3-0.2 vs 0.1 mm/year, 25-75%th: -0.3-0.4, P = 0.122) | ||
| 520 | |a CONCLUSION: This study found no significant difference regarding short-term and long-term outcomes in AS patients with/without moderate/severe AAD undergoing TAVR | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aortic aneurysm | |
| 650 | 4 | |a Aortic stenosis | |
| 650 | 4 | |a Bicuspid aortic valve | |
| 650 | 4 | |a TAVR | |
| 700 | 1 | |a Zhao, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Guannan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Can |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hongliang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Zhenyan |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Yunqing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhe |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Haiyan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Moyang |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yongjian |e verfasserin |4 aut | |
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