Epidemiology of Murine Typhus in Taiwan from 2013 to 2020
Murine typhus is a flea-borne disease caused by Rickettsia typhi infection. The disease is a notifiable infectious disease in Taiwan. Specimens from suspected cases are required to be sent to the Taiwan Centers for Disease Control and Prevention for laboratory diagnosis. In this study, 204 cases of murine typhus were identified by bacterial isolation, real-time polymerase chain reaction, or indirect immunofluorescence assay between 2013 and 2020. The average incidence rate was 0.11/100,000 person-years (95% CI: 0.08-0.13). Murine typhus occurred throughout the year, but it was most prevalent in summer (May to August). The majority of patients were males (75%), residents of Kaohsiung city (31%), and worked in agriculture, forestry, fishing, and animal husbandry (27%). Fever was the most common symptom, present in 95.6% of patients, followed by headache (41%), myalgia (33%), and liver dysfunction (33%). Only 13% of patients had a rash. Up to 80% of cases were among hospitalized patients, and 43% of patients developed severe manifestations. Serological assays also indicated coinfection events. Seven patients showed a 4-fold increase in antibody titers against Orientia tsutsugamushi (N = 2), Coxiella burnetii (n = 2), and Leptospira (N = 3). In conclusion, murine typhus is an endemic and important zoonotic rickettsial disease in Taiwan that cannot be ignored. Further epidemiological surveillance and clinical characteristics should be continuously investigated to prevent and control murine typhus.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:110 |
|---|---|
| Enthalten in: |
The American journal of tropical medicine and hygiene - 110(2024), 4 vom: 03. Apr., Seite 768-778 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hsueh, Yeou-Lin [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 05.04.2024 Date Revised 06.04.2024 published: Electronic-Print Citation Status MEDLINE |
|---|
| doi: |
10.4269/ajtmh.23-0155 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369608933 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369608933 | ||
| 003 | DE-627 | ||
| 005 | 20240406232257.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240313s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4269/ajtmh.23-0155 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1367.xml |
| 035 | |a (DE-627)NLM369608933 | ||
| 035 | |a (NLM)38471176 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hsueh, Yeou-Lin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epidemiology of Murine Typhus in Taiwan from 2013 to 2020 |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.04.2024 | ||
| 500 | |a Date Revised 06.04.2024 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Murine typhus is a flea-borne disease caused by Rickettsia typhi infection. The disease is a notifiable infectious disease in Taiwan. Specimens from suspected cases are required to be sent to the Taiwan Centers for Disease Control and Prevention for laboratory diagnosis. In this study, 204 cases of murine typhus were identified by bacterial isolation, real-time polymerase chain reaction, or indirect immunofluorescence assay between 2013 and 2020. The average incidence rate was 0.11/100,000 person-years (95% CI: 0.08-0.13). Murine typhus occurred throughout the year, but it was most prevalent in summer (May to August). The majority of patients were males (75%), residents of Kaohsiung city (31%), and worked in agriculture, forestry, fishing, and animal husbandry (27%). Fever was the most common symptom, present in 95.6% of patients, followed by headache (41%), myalgia (33%), and liver dysfunction (33%). Only 13% of patients had a rash. Up to 80% of cases were among hospitalized patients, and 43% of patients developed severe manifestations. Serological assays also indicated coinfection events. Seven patients showed a 4-fold increase in antibody titers against Orientia tsutsugamushi (N = 2), Coxiella burnetii (n = 2), and Leptospira (N = 3). In conclusion, murine typhus is an endemic and important zoonotic rickettsial disease in Taiwan that cannot be ignored. Further epidemiological surveillance and clinical characteristics should be continuously investigated to prevent and control murine typhus | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Chen, Hsiang-Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Mei-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Yen, Tsai-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Chien-Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Chiu, Hsien-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Huai-Chin |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Ya-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Shu, Pei-Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Su-Lin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The American journal of tropical medicine and hygiene |d 1945 |g 110(2024), 4 vom: 03. Apr., Seite 768-778 |w (DE-627)NLM000012513 |x 1476-1645 |7 nnns |
| 773 | 1 | 8 | |g volume:110 |g year:2024 |g number:4 |g day:03 |g month:04 |g pages:768-778 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4269/ajtmh.23-0155 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 110 |j 2024 |e 4 |b 03 |c 04 |h 768-778 | ||