Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism
RATIONALE: Chronic Thromboembolic Pulmonary Hypertension involves formation and non-resolution of thrombus, dysregulated inflammation, angiogenesis and the development of a small vessel vasculopathy.
OBJECTIVES: We aimed to establish the genetic basis of chronic thromboembolic pulmonary hypertension to gain insight into its pathophysiological contributors.
METHODS: We conducted a genome-wide association study on 1907 European cases and 10363 European controls. We co-analysed our results with existing results from genome-wide association studies on deep vein thrombosis, pulmonary embolism and idiopathic pulmonary arterial hypertension.
MEASUREMENTS AND MAIN RESULTS: Our primary association study revealed genetic associations at the ABO, FGG, F11, MYH7B, and HLA-DRA loci. Through our co-analysis we demonstrate further associations with chronic thromboembolic pulmonary hypertension at the F2, TSPAN15, SLC44A2 and F5 loci but find no statistically significant associations shared with idiopathic pulmonary arterial hypertension.
CONCLUSIONS: Chronic thromboembolic pulmonary hypertension is a partially heritable polygenic disease, with related though distinct genetic associations to pulmonary embolism and to deep vein thrombosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of respiratory and critical care medicine - (2024) vom: 12. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liley, James [VerfasserIn] |
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| Links: |
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| Themen: |
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) |
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| Anmerkungen: |
Date Revised 12.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1164/rccm.202307-1236OC |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369599489 |
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| 100 | 1 | |a Liley, James |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism |
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| 500 | |a Date Revised 12.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a RATIONALE: Chronic Thromboembolic Pulmonary Hypertension involves formation and non-resolution of thrombus, dysregulated inflammation, angiogenesis and the development of a small vessel vasculopathy | ||
| 520 | |a OBJECTIVES: We aimed to establish the genetic basis of chronic thromboembolic pulmonary hypertension to gain insight into its pathophysiological contributors | ||
| 520 | |a METHODS: We conducted a genome-wide association study on 1907 European cases and 10363 European controls. We co-analysed our results with existing results from genome-wide association studies on deep vein thrombosis, pulmonary embolism and idiopathic pulmonary arterial hypertension | ||
| 520 | |a MEASUREMENTS AND MAIN RESULTS: Our primary association study revealed genetic associations at the ABO, FGG, F11, MYH7B, and HLA-DRA loci. Through our co-analysis we demonstrate further associations with chronic thromboembolic pulmonary hypertension at the F2, TSPAN15, SLC44A2 and F5 loci but find no statistically significant associations shared with idiopathic pulmonary arterial hypertension | ||
| 520 | |a CONCLUSIONS: Chronic thromboembolic pulmonary hypertension is a partially heritable polygenic disease, with related though distinct genetic associations to pulmonary embolism and to deep vein thrombosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | |
| 650 | 4 | |a Conditional false discovery rate | |
| 650 | 4 | |a Genome wide association study | |
| 650 | 4 | |a Pulmonary Hypertension | |
| 650 | 4 | |a Pulmonary embolism | |
| 700 | 1 | |a Newnham, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Bleda, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Bunclark, Katherine |e verfasserin |4 aut | |
| 700 | 1 | |a Auger, William |e verfasserin |4 aut | |
| 700 | 1 | |a Barbera, Joan Albert |e verfasserin |4 aut | |
| 700 | 1 | |a Bogaard, Harm |e verfasserin |4 aut | |
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| 700 | 1 | |a Mayer, Eckhard |e verfasserin |4 aut | |
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