Simulated microgravity increases CD226+ Lin- CD117- Sca1+ mesenchymal stem cells in mice
© 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society..
Microgravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells. The development of novel MSCs biomarkers is critical for implementing effective therapies for microgravity induced bone loss. We aimed to find the new molecules involved in the differentiation and function of MSCs in mouse simulated microgravity model. We found CD226 was preferentially expressed on a subset of MSCs. Simulation of microgravity treatment significantly increased the proportion of CD226+ Lin- CD117- Sca1+ MSCs. The CD226+ MSCs produced higher IL-6, M-CSF, RANKL and lower CD200 expression, and promoted osteoclast differentiation. This study provides pivotal information to understand the role of CD226 in MSCs, and inspires new ideas for prevention of bone loss related diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Physiological reports - 12(2024), 5 vom: 14. März, Seite e15971 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhou, Wenjing [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarker |
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| Anmerkungen: |
Date Completed 13.03.2024 Date Revised 14.03.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.14814/phy2.15971 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369572831 |
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| 520 | |a © 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. | ||
| 520 | |a Microgravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells. The development of novel MSCs biomarkers is critical for implementing effective therapies for microgravity induced bone loss. We aimed to find the new molecules involved in the differentiation and function of MSCs in mouse simulated microgravity model. We found CD226 was preferentially expressed on a subset of MSCs. Simulation of microgravity treatment significantly increased the proportion of CD226+ Lin- CD117- Sca1+ MSCs. The CD226+ MSCs produced higher IL-6, M-CSF, RANKL and lower CD200 expression, and promoted osteoclast differentiation. This study provides pivotal information to understand the role of CD226 in MSCs, and inspires new ideas for prevention of bone loss related diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CD226 | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a mesenchymal stem cell | |
| 650 | 4 | |a simulated microgravity | |
| 700 | 1 | |a Li, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Yongli |e verfasserin |4 aut | |
| 700 | 1 | |a Dan, Wenli |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Lihua |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Liang |e verfasserin |4 aut | |
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