Characterization of chitosan/Persian gum nanoparticles for encapsulation of Nigella sativa extract as an antiviral agent against avian coronavirus
Copyright © 2024 Elsevier B.V. All rights reserved..
The aim of this study was to investigate the physicochemical characteristics of nanoparticles formed by the ionic gelation method between chitosan and water-soluble fraction of Persian gum (WPG) for encapsulation of Nigella sativa extract (NSE) as an antiviral agent. Our findings revealed that the particle size, polydispersity index (PDI), and zeta potential of the particles were in the range of 316.7-476.6 nm, 0.259-0.466, and 37.0-58.1 mV, respectively. The amounts of chitosan and WPG as the wall material and the NSE as the core had a considerable impact on the nanoparticle properties. The proper samples were detected at 1:1 chitosan:WPG mixing ratio (MR) and NSE concentration of 6.25 mg/mL. Fourier-transformed infrared (FTIR) spectroscopy proved the interactions between the two biopolymers. The effect of NSE on infectious bronchitis virus (IBV) known as avian coronavirus, was performed by the in-ovo method determining remarkable antiviral activity of NSE (25 mg/mL) and its enhancement through encapsulation in the nanoparticles. These nanoparticles containing NSE could have a promising capability for application in both poultry industry and human medicine as an antiviral product.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:265 |
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| Enthalten in: |
International journal of biological macromolecules - 265(2024), Pt 1 vom: 17. Apr., Seite 130749 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hadian, Mohammad [VerfasserIn] |
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| Links: |
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| Themen: |
9012-76-4 |
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| Anmerkungen: |
Date Completed 17.04.2024 Date Revised 17.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijbiomac.2024.130749 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369569458 |
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| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a The aim of this study was to investigate the physicochemical characteristics of nanoparticles formed by the ionic gelation method between chitosan and water-soluble fraction of Persian gum (WPG) for encapsulation of Nigella sativa extract (NSE) as an antiviral agent. Our findings revealed that the particle size, polydispersity index (PDI), and zeta potential of the particles were in the range of 316.7-476.6 nm, 0.259-0.466, and 37.0-58.1 mV, respectively. The amounts of chitosan and WPG as the wall material and the NSE as the core had a considerable impact on the nanoparticle properties. The proper samples were detected at 1:1 chitosan:WPG mixing ratio (MR) and NSE concentration of 6.25 mg/mL. Fourier-transformed infrared (FTIR) spectroscopy proved the interactions between the two biopolymers. The effect of NSE on infectious bronchitis virus (IBV) known as avian coronavirus, was performed by the in-ovo method determining remarkable antiviral activity of NSE (25 mg/mL) and its enhancement through encapsulation in the nanoparticles. These nanoparticles containing NSE could have a promising capability for application in both poultry industry and human medicine as an antiviral product | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antiviral activity | |
| 650 | 4 | |a Avian coronavirus | |
| 650 | 4 | |a Ionic gelation | |
| 650 | 4 | |a Nanoparticles | |
| 650 | 4 | |a Nigella sativa | |
| 650 | 7 | |a Chitosan |2 NLM | |
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| 700 | 1 | |a Fathi, Morteza |e verfasserin |4 aut | |
| 700 | 1 | |a Mohammadi, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Eskandari, Mohammad Hadi |e verfasserin |4 aut | |
| 700 | 1 | |a Asadsangabi, Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Pouraghajan, Khadijeh |e verfasserin |4 aut | |
| 700 | 1 | |a Shohrati, Majid |e verfasserin |4 aut | |
| 700 | 1 | |a Mohammadpour, Masoomeh |e verfasserin |4 aut | |
| 700 | 1 | |a Samadi, Mohammad |e verfasserin |4 aut | |
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