Perspectives About Ascorbic Acid to Treat Inflammatory Bowel Diseases
Thieme. All rights reserved..
It is known that reactive oxygen species cause abnormal immune responses in the gut during inflammatory bowel diseases (IBD). Therefore, oxidative stress has been theorized as an agent of IBD development and antioxidant compounds such as vitamin C (L-ascorbic acid) have been studied as a new tool to treat IBD. Therefore, the potential of vitamin C to treat IBD was reviewed here as a critical discussion about this field and guide future research. Indeed, some preclinical studies have shown the beneficial effects of vitamin C in models of ulcerative colitis in mice and clinical and experimental findings have shown that deficiency in this vitamin is associated with the development of IBD and its worsening. The main mechanisms that may be involved in the activity of ascorbic acid in IBD include its well-established role as an antioxidant, but also others diversified actions. However, some experimental studies employed high doses of vitamin C and most of them did not perform dose-response curves and neither determined the minimum effective dose nor the ED50. Allometric extrapolations were also not made. Also, clinical studies on the subject are still in their infancy. Therefore, it is suggested that the research agenda in this matter covers experimental studies that assess the effective, safe, and translational doses, as well as the appropriate administration route and its action mechanism. After that, robust clinical trials to increase knowledge about the role of ascorbic acid deficiency in IBD patients and the effects of their supplementation in these patients can be encouraged.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
---|---|
Enthalten in: |
Drug research - 74(2024), 4 vom: 11. Apr., Seite 149-155 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Andriolo, Ian Richard Lucena [VerfasserIn] |
---|
Links: |
---|
Themen: |
1406-16-2 |
---|
Anmerkungen: |
Date Completed 10.04.2024 Date Revised 10.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1055/a-2263-1388 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369568915 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369568915 | ||
003 | DE-627 | ||
005 | 20240410232646.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240312s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1055/a-2263-1388 |2 doi | |
028 | 5 | 2 | |a pubmed24n1371.xml |
035 | |a (DE-627)NLM369568915 | ||
035 | |a (NLM)38467159 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Andriolo, Ian Richard Lucena |e verfasserin |4 aut | |
245 | 1 | 0 | |a Perspectives About Ascorbic Acid to Treat Inflammatory Bowel Diseases |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 10.04.2024 | ||
500 | |a Date Revised 10.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Thieme. All rights reserved. | ||
520 | |a It is known that reactive oxygen species cause abnormal immune responses in the gut during inflammatory bowel diseases (IBD). Therefore, oxidative stress has been theorized as an agent of IBD development and antioxidant compounds such as vitamin C (L-ascorbic acid) have been studied as a new tool to treat IBD. Therefore, the potential of vitamin C to treat IBD was reviewed here as a critical discussion about this field and guide future research. Indeed, some preclinical studies have shown the beneficial effects of vitamin C in models of ulcerative colitis in mice and clinical and experimental findings have shown that deficiency in this vitamin is associated with the development of IBD and its worsening. The main mechanisms that may be involved in the activity of ascorbic acid in IBD include its well-established role as an antioxidant, but also others diversified actions. However, some experimental studies employed high doses of vitamin C and most of them did not perform dose-response curves and neither determined the minimum effective dose nor the ED50. Allometric extrapolations were also not made. Also, clinical studies on the subject are still in their infancy. Therefore, it is suggested that the research agenda in this matter covers experimental studies that assess the effective, safe, and translational doses, as well as the appropriate administration route and its action mechanism. After that, robust clinical trials to increase knowledge about the role of ascorbic acid deficiency in IBD patients and the effects of their supplementation in these patients can be encouraged | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a Ascorbic Acid |2 NLM | |
650 | 7 | |a PQ6CK8PD0R |2 NLM | |
650 | 7 | |a Vitamin D |2 NLM | |
650 | 7 | |a 1406-16-2 |2 NLM | |
650 | 7 | |a Antioxidants |2 NLM | |
700 | 1 | |a Venzon, Larissa |e verfasserin |4 aut | |
700 | 1 | |a da Silva, Luisa Mota |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Drug research |d 2013 |g 74(2024), 4 vom: 11. Apr., Seite 149-155 |w (DE-627)NLM225192764 |x 2194-9387 |7 nnns |
773 | 1 | 8 | |g volume:74 |g year:2024 |g number:4 |g day:11 |g month:04 |g pages:149-155 |
856 | 4 | 0 | |u http://dx.doi.org/10.1055/a-2263-1388 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 74 |j 2024 |e 4 |b 11 |c 04 |h 149-155 |