Exploring the efficacy and safety of Drug-Eluting beads transarterial chemoembolization in pancreatic cancer liver metastasis
© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissionsoup.com..
OBJECTIVE: Drug-eluting beads transarterial chemoembolization (DEB-TACE) has shown promise as a treatment modality for primary liver cancer and colorectal cancer liver metastasis. However, its role in pancreatic cancer liver metastasis (PCLM) remains uncertain. This study aimed to investigate the efficacy and safety of DEB-TACE in PCLM patients.
METHODS: A retrospective study included 10 PCLM patients who underwent DEB-TACE using CalliSpheres® microspheres as the chemoembolization material. Treatment response, survival outcomes, adverse events, and liver function indexes were comprehensively assessed.
RESULTS: Among the patients, complete response, partial response, stable disease, and progressive disease rates were 0.0%, 40.0%, 30.0%, and 30.0%, respectively. The objective response rate was 40.0%, and the disease-control rate was 70.0%. The median progression-free survival (PFS) was 12.0 months (95% CI: 0.0-26.7), with a 1-year PFS rate of 48.0%. The median overall survival (OS) was 18.0 months (95% CI: 6.0-30.0), with a 1-year OS rate of 80.0%. Additionally, no significant differences were observed in any of the liver function indexes, including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, etc, between pre-and post-treatment evaluations. Adverse events included pain, grade 1-2 vomiting, fever, and transient liver dysfunction.
CONCLUSION: DEB-TACE demonstrates a promising treatment response, favorable survival profile, and satisfactory safety in PCLM patients.
ADVANCES IN KNOWLEDGE: This study adds to the current research by providing novel evidence on the efficacy, safety, and favorable survival outcomes of DEB-TACE in treating PCLM, highlighting its potential as an effective therapeutic option in this specific population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The British journal of radiology - (2024) vom: 11. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ning, Zhouyu [VerfasserIn] |
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| Links: |
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| Themen: |
Drug-eluting beads |
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| Anmerkungen: |
Date Revised 11.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1093/bjr/tqae059 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a OBJECTIVE: Drug-eluting beads transarterial chemoembolization (DEB-TACE) has shown promise as a treatment modality for primary liver cancer and colorectal cancer liver metastasis. However, its role in pancreatic cancer liver metastasis (PCLM) remains uncertain. This study aimed to investigate the efficacy and safety of DEB-TACE in PCLM patients | ||
| 520 | |a METHODS: A retrospective study included 10 PCLM patients who underwent DEB-TACE using CalliSpheres® microspheres as the chemoembolization material. Treatment response, survival outcomes, adverse events, and liver function indexes were comprehensively assessed | ||
| 520 | |a RESULTS: Among the patients, complete response, partial response, stable disease, and progressive disease rates were 0.0%, 40.0%, 30.0%, and 30.0%, respectively. The objective response rate was 40.0%, and the disease-control rate was 70.0%. The median progression-free survival (PFS) was 12.0 months (95% CI: 0.0-26.7), with a 1-year PFS rate of 48.0%. The median overall survival (OS) was 18.0 months (95% CI: 6.0-30.0), with a 1-year OS rate of 80.0%. Additionally, no significant differences were observed in any of the liver function indexes, including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, etc, between pre-and post-treatment evaluations. Adverse events included pain, grade 1-2 vomiting, fever, and transient liver dysfunction | ||
| 520 | |a CONCLUSION: DEB-TACE demonstrates a promising treatment response, favorable survival profile, and satisfactory safety in PCLM patients | ||
| 520 | |a ADVANCES IN KNOWLEDGE: This study adds to the current research by providing novel evidence on the efficacy, safety, and favorable survival outcomes of DEB-TACE in treating PCLM, highlighting its potential as an effective therapeutic option in this specific population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a drug-eluting beads | |
| 650 | 4 | |a efficacy | |
| 650 | 4 | |a pancreatic cancer liver metastasis | |
| 650 | 4 | |a safety | |
| 650 | 4 | |a survival outcomes | |
| 650 | 4 | |a transarterial chemoembolization | |
| 700 | 1 | |a Zhu, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Hua, Yongqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Zhiqiang |e verfasserin |4 aut | |
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