No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway
Copyright: © 2024 Bøås et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..
OBJECTIVE: There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between disease severity and RSV subtypes RSV-A and RSV-B and to describe the circulation of RSV subtypes pattern by season and age.
METHODS: Active prospective hospital surveillance for RSV-A and RSV-B in children <59 months of age was conducted during 2015-2018. All febrile children 12-59 months of age were enrolled, whereas children <12 months were eligible if presenting with fever or respiratory symptoms. Risk factors and upper and lower respiratory tract infection was identified by linkage to national registry data and analyzed using penalized maximum likelihood logistic regression.
RESULTS: Both RSV-A and B were found to co-circulate throughout all three study seasons, and no clear seasonal pattern was identified. Likewise, we found no association between sex or measures of severity with RSV-A or RSV-B. There was significantly more RSV-A than RSV-B among children with comorbidities.
CONCLUSIONS: No association was found between disease severity or sex and RSV subtypes RSV-A and RSV-B in hospitalized young children in Norway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
PloS one - 19(2024), 3 vom: 11., Seite e0298104 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bøås, Håkon [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.03.2024 Date Revised 13.03.2024 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0298104 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369564340 |
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| 245 | 1 | 0 | |a No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright: © 2024 Bøås et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
| 520 | |a OBJECTIVE: There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between disease severity and RSV subtypes RSV-A and RSV-B and to describe the circulation of RSV subtypes pattern by season and age | ||
| 520 | |a METHODS: Active prospective hospital surveillance for RSV-A and RSV-B in children <59 months of age was conducted during 2015-2018. All febrile children 12-59 months of age were enrolled, whereas children <12 months were eligible if presenting with fever or respiratory symptoms. Risk factors and upper and lower respiratory tract infection was identified by linkage to national registry data and analyzed using penalized maximum likelihood logistic regression | ||
| 520 | |a RESULTS: Both RSV-A and B were found to co-circulate throughout all three study seasons, and no clear seasonal pattern was identified. Likewise, we found no association between sex or measures of severity with RSV-A or RSV-B. There was significantly more RSV-A than RSV-B among children with comorbidities | ||
| 520 | |a CONCLUSIONS: No association was found between disease severity or sex and RSV subtypes RSV-A and RSV-B in hospitalized young children in Norway | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Havdal, Lise Beier |e verfasserin |4 aut | |
| 700 | 1 | |a Størdal, Ketil |e verfasserin |4 aut | |
| 700 | 1 | |a Døllner, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Leegaard, Truls Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Bekkevold, Terese |e verfasserin |4 aut | |
| 700 | 1 | |a Flem, Elmira |e verfasserin |4 aut | |
| 700 | 1 | |a Inchley, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Nordbø, Svein Arne |e verfasserin |4 aut | |
| 700 | 1 | |a Rojahn, Astrid Elisabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Debes, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Barstad, Bjørn |e verfasserin |4 aut | |
| 700 | 1 | |a Haarr, Elisebet |e verfasserin |4 aut | |
| 700 | 1 | |a Kran, Anne-Marte Bakken |e verfasserin |4 aut | |
| 700 | 0 | |a Norwegian Enhanced Pediatric Immunisation Surveillance (NorEPIS) Network |e verfasserin |4 aut | |
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