Emergence, Pattern, and Frequency of Spontaneous Waves in Spreading Epithelial Monolayers
A striking phenomenon of collective cell motion is that they can exhibit a spontaneously emerging wave during epithelia expansions. However, the fundamental mechanism, governing the emergence and its crucial characteristics (e.g., the eigenfrequency and the pattern), remains an enigma. By introducing a mechanochemical feedback loop, we develop a highly efficient discrete vertex model to investigate the spatiotemporal evolution of spreading epithelia. We find both numerically and analytically that expanding cell monolayers display a power-law dependence of wave frequency on the local heterogeneities (i.e., cell density) with a scaling exponent of -1/2. Moreover, our study demonstrates the quantitative capability of the proposed model in capturing distinct X-, W-, and V-mode wave patterns. We unveil that the phase transition between these modes is governed by the distribution of active self-propulsion forces. Our work provides an avenue for rigorous quantitative investigations into the collective motion and pattern formation of cell groups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Nano letters - 24(2024), 12 vom: 27. März, Seite 3631-3637 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yin, Xu [VerfasserIn] |
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| Links: |
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| Themen: |
Applied mechanics |
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| Anmerkungen: |
Date Revised 27.03.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.nanolett.3c04876 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369559673 |
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| 520 | |a A striking phenomenon of collective cell motion is that they can exhibit a spontaneously emerging wave during epithelia expansions. However, the fundamental mechanism, governing the emergence and its crucial characteristics (e.g., the eigenfrequency and the pattern), remains an enigma. By introducing a mechanochemical feedback loop, we develop a highly efficient discrete vertex model to investigate the spatiotemporal evolution of spreading epithelia. We find both numerically and analytically that expanding cell monolayers display a power-law dependence of wave frequency on the local heterogeneities (i.e., cell density) with a scaling exponent of -1/2. Moreover, our study demonstrates the quantitative capability of the proposed model in capturing distinct X-, W-, and V-mode wave patterns. We unveil that the phase transition between these modes is governed by the distribution of active self-propulsion forces. Our work provides an avenue for rigorous quantitative investigations into the collective motion and pattern formation of cell groups | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Applied mechanics | |
| 650 | 4 | |a Collective migration | |
| 650 | 4 | |a Mechanical wave | |
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| 700 | 1 | |a Zhang, Li-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Guang-Kui |e verfasserin |4 aut | |
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