Nickel-Catalyzed Deoxygenative Amidation of Alcohols with Carbamoyl Chlorides
We report a deoxygenative amidation reaction of alcohols with carbamoyl chlorides to afford amides through nickel-photoredox dual catalysis. Good to excellent yields can be obtained even for diverse complex sugar and steroid derivatives. The reaction is scalable, and the synthetic utility of the reaction was demonstrated by the homologation of alcohols to deliver several important γ-amino alcohols and a synthetically challenging bioactive compound intermediate.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Organic letters - 26(2024), 11 vom: 22. März, Seite 2297-2302 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Lele [VerfasserIn] |
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| Anmerkungen: |
Date Revised 22.03.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.4c00519 |
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| funding: |
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NLM369556186 |
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| 520 | |a We report a deoxygenative amidation reaction of alcohols with carbamoyl chlorides to afford amides through nickel-photoredox dual catalysis. Good to excellent yields can be obtained even for diverse complex sugar and steroid derivatives. The reaction is scalable, and the synthetic utility of the reaction was demonstrated by the homologation of alcohols to deliver several important γ-amino alcohols and a synthetically challenging bioactive compound intermediate | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Li, Zhongxian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Jun |e verfasserin |4 aut | |
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