Functions of IgM fc receptor (FcµR) related to autoimmunity
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with FCMR deficiency and the model for FcµR-mediated regulation of self-reactive B cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
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| Enthalten in: |
Autoimmunity - 57(2024), 1 vom: 05. März, Seite 2323563 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kubagawa, Hiromi [VerfasserIn] |
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| Links: |
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| Themen: |
Autoantibodies |
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| Anmerkungen: |
Date Completed 12.03.2024 Date Revised 12.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/08916934.2024.2323563 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with FCMR deficiency and the model for FcµR-mediated regulation of self-reactive B cells | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Honjo, Kazuhito |e verfasserin |4 aut | |
| 700 | 1 | |a Izui, Shozo |e verfasserin |4 aut | |
| 700 | 1 | |a Radbruch, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Melchers, Fritz |e verfasserin |4 aut | |
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