Differential Impact of Fractional Flow Reserve Measured After Coronary Stent Implantation by Left Ventricular Dysfunction
© 2024 The Authors..
Background: Both left ventricular systolic function and fractional flow reserve (FFR) are prognostic factors after percutaneous coronary intervention (PCI). However, how these prognostic factors are inter-related in risk stratification of patients after PCI remains unclarified.
Objectives: This study evaluated differential prognostic implication of post-PCI FFR according to left ventricular ejection fraction (LVEF).
Methods: A total of 2,965 patients with available LVEF were selected from the POST-PCI FLOW (Prognostic Implications of Physiologic Investigation After Revascularization with Stent) international registry of patients with post-PCI FFR measurement. The primary outcome was a composite of cardiac death or target-vessel myocardial infarction (TVMI) at 2 years. The secondary outcome was target-vessel revascularization (TVR) and target vessel failure, which was a composite of cardiac death, TVMI, or TVR.
Results: Post-PCI FFR was independently associated with the risk of target vessel failure (per 0.01 decrease: HRadj: 1.029; 95% CI: 1.009-1.049; P = 0.005). Post-PCI FFR was associated with increased risk of cardiac death or TVMI (HRadj: 1.145; 95% CI: 1.025-1.280; P = 0.017) among patients with LVEF ≤40%, and with that of TVR in patients with LVEF >40% (HRadj: 1.028; 95% CI: 1.005-1.052; P = 0.020). Post-PCI FFR ≤0.80 was associated with increased risk of cardiac death or TVMI in the LVEF ≤40% group and with that of TVR in LVEF >40% group. Prognostic impact of post-PCI FFR for the primary outcome was significantly different according to LVEF (Pinteraction = 0.019).
Conclusions: Post-PCI FFR had differential prognostic impact according to LVEF. Residual ischemia by post-PCI FFR ≤0.80 was a prognostic indicator for cardiac death or TVMI among patients with patients with LVEF ≤40%, and it was associated with TVR among patients with patients with LVEF>40%. (Prognostic Implications of Physiologic Investigation After Revascularization with Stent [POST-PCI FLOW]; NCT04684043).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
|---|---|
| Enthalten in: |
JACC. Asia - 4(2024), 3 vom: 02. März, Seite 229-240 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Choi, Ki Hong [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Drug-eluting stent(s) |
|---|
| Anmerkungen: |
Date Revised 12.03.2024 published: Electronic-eCollection ClinicalTrials.gov: NCT04684043 Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1016/j.jacasi.2023.10.009 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369534069 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369534069 | ||
| 003 | DE-627 | ||
| 005 | 20240312234320.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240311s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jacasi.2023.10.009 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1324.xml |
| 035 | |a (DE-627)NLM369534069 | ||
| 035 | |a (NLM)38463680 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Choi, Ki Hong |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Differential Impact of Fractional Flow Reserve Measured After Coronary Stent Implantation by Left Ventricular Dysfunction |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 12.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a ClinicalTrials.gov: NCT04684043 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024 The Authors. | ||
| 520 | |a Background: Both left ventricular systolic function and fractional flow reserve (FFR) are prognostic factors after percutaneous coronary intervention (PCI). However, how these prognostic factors are inter-related in risk stratification of patients after PCI remains unclarified | ||
| 520 | |a Objectives: This study evaluated differential prognostic implication of post-PCI FFR according to left ventricular ejection fraction (LVEF) | ||
| 520 | |a Methods: A total of 2,965 patients with available LVEF were selected from the POST-PCI FLOW (Prognostic Implications of Physiologic Investigation After Revascularization with Stent) international registry of patients with post-PCI FFR measurement. The primary outcome was a composite of cardiac death or target-vessel myocardial infarction (TVMI) at 2 years. The secondary outcome was target-vessel revascularization (TVR) and target vessel failure, which was a composite of cardiac death, TVMI, or TVR | ||
| 520 | |a Results: Post-PCI FFR was independently associated with the risk of target vessel failure (per 0.01 decrease: HRadj: 1.029; 95% CI: 1.009-1.049; P = 0.005). Post-PCI FFR was associated with increased risk of cardiac death or TVMI (HRadj: 1.145; 95% CI: 1.025-1.280; P = 0.017) among patients with LVEF ≤40%, and with that of TVR in patients with LVEF >40% (HRadj: 1.028; 95% CI: 1.005-1.052; P = 0.020). Post-PCI FFR ≤0.80 was associated with increased risk of cardiac death or TVMI in the LVEF ≤40% group and with that of TVR in LVEF >40% group. Prognostic impact of post-PCI FFR for the primary outcome was significantly different according to LVEF (Pinteraction = 0.019) | ||
| 520 | |a Conclusions: Post-PCI FFR had differential prognostic impact according to LVEF. Residual ischemia by post-PCI FFR ≤0.80 was a prognostic indicator for cardiac death or TVMI among patients with patients with LVEF ≤40%, and it was associated with TVR among patients with patients with LVEF>40%. (Prognostic Implications of Physiologic Investigation After Revascularization with Stent [POST-PCI FLOW]; NCT04684043) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a drug-eluting stent(s) | |
| 650 | 4 | |a fractional flow reserve | |
| 650 | 4 | |a left ventricular ejection fraction | |
| 650 | 4 | |a percutaneous coronary intervention | |
| 650 | 4 | |a prognosis | |
| 700 | 1 | |a Kwon, Woochan |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Doosup |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Seung-Hun |e verfasserin |4 aut | |
| 700 | 1 | |a Hwang, Doyeon |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jinlong |e verfasserin |4 aut | |
| 700 | 1 | |a Nam, Chang-Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Eun-Seok |e verfasserin |4 aut | |
| 700 | 1 | |a Doh, Joon-Hyung |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Shao-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Kakuta, Tsunekazu |e verfasserin |4 aut | |
| 700 | 1 | |a Toth, Gabor G |e verfasserin |4 aut | |
| 700 | 1 | |a Piroth, Zsolt |e verfasserin |4 aut | |
| 700 | 1 | |a Hakeem, Abdul |e verfasserin |4 aut | |
| 700 | 1 | |a Uretsky, Barry F |e verfasserin |4 aut | |
| 700 | 1 | |a Hokama, Yohei |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Nobuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Hong-Seok |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Tsuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuo, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Azzalini, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Leesar, Massoud A |e verfasserin |4 aut | |
| 700 | 1 | |a Daemen, Joost |e verfasserin |4 aut | |
| 700 | 1 | |a Collison, Damien |e verfasserin |4 aut | |
| 700 | 1 | |a Collet, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a De Bruyne, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Koo, Bon-Kwon |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Taek Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jeong Hoon |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Young Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Hahn, Joo-Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Seung-Hyuk |e verfasserin |4 aut | |
| 700 | 1 | |a Gwon, Hyeon-Cheol |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Joo Myung |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t JACC. Asia |d 2021 |g 4(2024), 3 vom: 02. März, Seite 229-240 |w (DE-627)NLM348520204 |x 2772-3747 |7 nnns |
| 773 | 1 | 8 | |g volume:4 |g year:2024 |g number:3 |g day:02 |g month:03 |g pages:229-240 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jacasi.2023.10.009 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 4 |j 2024 |e 3 |b 02 |c 03 |h 229-240 | ||