A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy
© 2024 The Authors..
Much effort has been devoted to improving treatment efficiency for osteosarcoma (OS). However, most current approaches result in poor therapeutic responses, thus indicating the need for the development of other therapeutic options. This study developed a multifunctional nanoparticle, PDA-MOF-E-M, an aggregation of OS targeting, programmed death targeting, and near-infrared (NIR)-aided targeting. At the same time, a multifunctional nanoparticle that utilises Fe-MOFs to create a cellular iron-rich environment and erastin as a ferroptosis inducer while ensuring targeted delivery to OS cells through cell membrane encapsulation is presented. The combination of PDA-MOF-E-M and PTT increased intracellular ROS and LPO levels and induced ferroptosis-related protein expression. A PDA-based PTT combined with erastin showed significant synergistic therapeutic improvement in the anti-tumour efficiency of the nanoparticle in vitro and vivo. The multifunctional nanoparticle efficiently prevents the osteoclasia progression of OS xenograft bone tumors in vivo. Finally, this study provides guidance and a point of reference for clinical approaches to treating OS.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
---|---|
Enthalten in: |
Bioactive materials - 36(2024) vom: 28. März, Seite 157-167 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Liu, Yu-Jie [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Revised 12.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1016/j.bioactmat.2024.02.007 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369532805 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369532805 | ||
003 | DE-627 | ||
005 | 20240312234311.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240311s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.bioactmat.2024.02.007 |2 doi | |
028 | 5 | 2 | |a pubmed24n1324.xml |
035 | |a (DE-627)NLM369532805 | ||
035 | |a (NLM)38463554 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Liu, Yu-Jie |e verfasserin |4 aut | |
245 | 1 | 2 | |a A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 12.03.2024 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2024 The Authors. | ||
520 | |a Much effort has been devoted to improving treatment efficiency for osteosarcoma (OS). However, most current approaches result in poor therapeutic responses, thus indicating the need for the development of other therapeutic options. This study developed a multifunctional nanoparticle, PDA-MOF-E-M, an aggregation of OS targeting, programmed death targeting, and near-infrared (NIR)-aided targeting. At the same time, a multifunctional nanoparticle that utilises Fe-MOFs to create a cellular iron-rich environment and erastin as a ferroptosis inducer while ensuring targeted delivery to OS cells through cell membrane encapsulation is presented. The combination of PDA-MOF-E-M and PTT increased intracellular ROS and LPO levels and induced ferroptosis-related protein expression. A PDA-based PTT combined with erastin showed significant synergistic therapeutic improvement in the anti-tumour efficiency of the nanoparticle in vitro and vivo. The multifunctional nanoparticle efficiently prevents the osteoclasia progression of OS xenograft bone tumors in vivo. Finally, this study provides guidance and a point of reference for clinical approaches to treating OS | ||
650 | 4 | |a Journal Article | |
700 | 1 | |a Dong, Su-He |e verfasserin |4 aut | |
700 | 1 | |a Hu, Wen-Hao |e verfasserin |4 aut | |
700 | 1 | |a Chen, Qiao-Ling |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Shao-Fu |e verfasserin |4 aut | |
700 | 1 | |a Song, Kai |e verfasserin |4 aut | |
700 | 1 | |a Han, Zhen-Chuan |e verfasserin |4 aut | |
700 | 1 | |a Li, Meng-Meng |e verfasserin |4 aut | |
700 | 1 | |a Han, Zhi-Tao |e verfasserin |4 aut | |
700 | 1 | |a Liu, Wei-Bo |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Xue-Song |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Bioactive materials |d 2016 |g 36(2024) vom: 28. März, Seite 157-167 |w (DE-627)NLM270377816 |x 2452-199X |7 nnns |
773 | 1 | 8 | |g volume:36 |g year:2024 |g day:28 |g month:03 |g pages:157-167 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bioactmat.2024.02.007 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 36 |j 2024 |b 28 |c 03 |h 157-167 |