Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization
© 2024 The Authors..
Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose a multi-functional composite hydrogel engineered to overcome such conditions through recruitment and activation of macrophages with adapted degradation of the hydrogel. The composite hydrogel (G-TSrP) is created by combining gelatin methacryloyl (GelMA) and nanoparticles (TSrP) composed of tannic acid (TA) and Sr2+. These nanoparticles are prepared using a one-step mineralization process assisted by metal-phenolic network formation. G-TSrP exhibits the ability to eliminate reactive oxygen species and direct polarization of macrophages toward M2 phenotype. It has been observed that the liberation of TA and Sr2+ from G-TSrP actively facilitate the recruitment and up-regulation of the expression of extracellular matrix remodeling genes of macrophages, and thereby, coordinate in vivo adapted degradation of the G-TSrP. Most significantly, G-TSrP accelerates angiogenesis despite the TA's inhibitory properties, which are counteracted by the released Sr2+. Moreover, G-TSrP enhances wound closure under inflammation and promotes normal tissue formation with strong vessel growth. Genetic analysis confirms macrophage-mediated wound healing by the composite hydrogel. Collectively, these findings pave the way for the development of biomaterials that promote wound healing by creating regenerative environment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Bioactive materials - 36(2024) vom: 28. März, Seite 185-202 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Byun, Hayeon [VerfasserIn] |
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| Links: |
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| Themen: |
Composite hydrogels |
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| Anmerkungen: |
Date Revised 12.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.bioactmat.2024.02.029 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369532783 |
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| 520 | |a © 2024 The Authors. | ||
| 520 | |a Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose a multi-functional composite hydrogel engineered to overcome such conditions through recruitment and activation of macrophages with adapted degradation of the hydrogel. The composite hydrogel (G-TSrP) is created by combining gelatin methacryloyl (GelMA) and nanoparticles (TSrP) composed of tannic acid (TA) and Sr2+. These nanoparticles are prepared using a one-step mineralization process assisted by metal-phenolic network formation. G-TSrP exhibits the ability to eliminate reactive oxygen species and direct polarization of macrophages toward M2 phenotype. It has been observed that the liberation of TA and Sr2+ from G-TSrP actively facilitate the recruitment and up-regulation of the expression of extracellular matrix remodeling genes of macrophages, and thereby, coordinate in vivo adapted degradation of the G-TSrP. Most significantly, G-TSrP accelerates angiogenesis despite the TA's inhibitory properties, which are counteracted by the released Sr2+. Moreover, G-TSrP enhances wound closure under inflammation and promotes normal tissue formation with strong vessel growth. Genetic analysis confirms macrophage-mediated wound healing by the composite hydrogel. Collectively, these findings pave the way for the development of biomaterials that promote wound healing by creating regenerative environment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Composite hydrogels | |
| 650 | 4 | |a Immunomodulation | |
| 650 | 4 | |a Multi-functional nanoparticles | |
| 650 | 4 | |a Neovascularization | |
| 650 | 4 | |a Wound healing | |
| 700 | 1 | |a Han, Yujin |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Eunhyung |e verfasserin |4 aut | |
| 700 | 1 | |a Jun, Indong |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jinkyu |e verfasserin |4 aut | |
| 700 | 1 | |a Jeong, Hyewoo |e verfasserin |4 aut | |
| 700 | 1 | |a Huh, Seung Jae |e verfasserin |4 aut | |
| 700 | 1 | |a Joo, Jinmyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Su Ryon |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Heungsoo |e verfasserin |4 aut | |
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