Prevalence and prognosis of fulminant type 1 diabetes mellitus in The Middle East : a comparative analysis in a 5-year nationwide cohort
© 2024. The Author(s)..
PURPOSE: To analyze the prevalence and progression of fulminant type 1 diabetes (FT1D) in Qatar.
METHODS: This retrospective study analyzed consecutive index- diabetic ketoacidosis (DKA) admissions (2015-2020) among patients with new-onset T1D (NT1D) in Qatar.
RESULTS: Of the 242 patients, 2.5% fulfilled the FT1D diagnostic criteria. FT1D patients were younger (median-age 4-years vs.15-years in classic-T1D). Gender distribution in FT1D was equal, whereas the classic-T1D group showed a female predominance at 57.6% (n = 136). FT1D patients had a mean C-peptide of 0.11 ± 0.09 ng/ml, compared to 0.53 ± 0.45 ng/ml in classic-T1D. FT1D patients had a median length of stay (LOS) of 1 day (1-2.2) and a DKA duration of 11.25 h (11-15). The median (length of stay) LOS and DKA duration in classic-T1D patients were 2.5 days (1-3.9) and 15.4 h (11-23), respectively. The FT1D subset primarily consisted of moderate (83.3%) and severe 916.7%) DKA, whereas classic T1D had 25.4% mild, 60.6% moderate, and 14% severe DKA cases. FT1D was associated with a higher median white cell count (22.3 × 103/uL) at admission compared to classic T1D (10.6 × 103/uL). ICU admission was needed for 66.6% of FT1D patients, compared to 38.1% of classic-T1D patients. None of the patients in the FT1D group had mortality, while two died in the classic-T1D group.
CONCLUSION: This is the first study establishing the existence of FT1D in ME, which presented distinctively from classic-T1D, exhibiting earlier age onset and higher critical care requirements. However, the clinical outcomes in patients with FT1D seem similar to classic T1D.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
BMC endocrine disorders - 24(2024), 1 vom: 11. März, Seite 33 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ata, Fateen [VerfasserIn] |
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| Links: |
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| Themen: |
Classic Type 1 diabetes |
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| Anmerkungen: |
Date Completed 12.03.2024 Date Revised 13.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12902-024-01559-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369523334 |
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| 100 | 1 | |a Ata, Fateen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevalence and prognosis of fulminant type 1 diabetes mellitus in The Middle East |b a comparative analysis in a 5-year nationwide cohort |
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| 500 | |a Date Revised 13.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a PURPOSE: To analyze the prevalence and progression of fulminant type 1 diabetes (FT1D) in Qatar | ||
| 520 | |a METHODS: This retrospective study analyzed consecutive index- diabetic ketoacidosis (DKA) admissions (2015-2020) among patients with new-onset T1D (NT1D) in Qatar | ||
| 520 | |a RESULTS: Of the 242 patients, 2.5% fulfilled the FT1D diagnostic criteria. FT1D patients were younger (median-age 4-years vs.15-years in classic-T1D). Gender distribution in FT1D was equal, whereas the classic-T1D group showed a female predominance at 57.6% (n = 136). FT1D patients had a mean C-peptide of 0.11 ± 0.09 ng/ml, compared to 0.53 ± 0.45 ng/ml in classic-T1D. FT1D patients had a median length of stay (LOS) of 1 day (1-2.2) and a DKA duration of 11.25 h (11-15). The median (length of stay) LOS and DKA duration in classic-T1D patients were 2.5 days (1-3.9) and 15.4 h (11-23), respectively. The FT1D subset primarily consisted of moderate (83.3%) and severe 916.7%) DKA, whereas classic T1D had 25.4% mild, 60.6% moderate, and 14% severe DKA cases. FT1D was associated with a higher median white cell count (22.3 × 103/uL) at admission compared to classic T1D (10.6 × 103/uL). ICU admission was needed for 66.6% of FT1D patients, compared to 38.1% of classic-T1D patients. None of the patients in the FT1D group had mortality, while two died in the classic-T1D group | ||
| 520 | |a CONCLUSION: This is the first study establishing the existence of FT1D in ME, which presented distinctively from classic-T1D, exhibiting earlier age onset and higher critical care requirements. However, the clinical outcomes in patients with FT1D seem similar to classic T1D | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Classic Type 1 diabetes | |
| 650 | 4 | |a DKA | |
| 650 | 4 | |a Diabetes mellitus | |
| 650 | 4 | |a Diabetic ketoacidosis | |
| 650 | 4 | |a Fulminant type 1 diabetes | |
| 700 | 1 | |a Khan, Adeel Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Khamees, Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a AlKodmani, Sham |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Sadi, Anas |e verfasserin |4 aut | |
| 700 | 1 | |a Yaseen, Khaled Bani |e verfasserin |4 aut | |
| 700 | 1 | |a Muthanna, Bassam |e verfasserin |4 aut | |
| 700 | 1 | |a Godwin, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Beer, Stephen Frederick |e verfasserin |4 aut | |
| 700 | 1 | |a Bashir, Mohammed |e verfasserin |4 aut | |
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