Genetic variation drives differences in obesity-related gene regulation
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved..
Heikkinen and colleagues recently demonstrated that genetic variation, rather than dietary changes, governs gene regulation in liver. This finding highlights the impact of noncoding variants on chromatin accessibility, histone modifications, transcription factor binding, and gene expression and has implications for future research directions in understanding the genetic basis of disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Trends in genetics : TIG - 40(2024), 4 vom: 09. Apr., Seite 296-298 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kaikkonen, Minna U [VerfasserIn] |
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| Links: |
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| Themen: |
Chromatin |
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| Anmerkungen: |
Date Completed 11.04.2024 Date Revised 11.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.tig.2024.02.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369521285 |
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| 520 | |a Heikkinen and colleagues recently demonstrated that genetic variation, rather than dietary changes, governs gene regulation in liver. This finding highlights the impact of noncoding variants on chromatin accessibility, histone modifications, transcription factor binding, and gene expression and has implications for future research directions in understanding the genetic basis of disease | ||
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