Exploring the pathophysiological influence of heme oxygenase-1 on neuroinflammation and depression : A study of phytotherapeutic-based modulation
Copyright © 2024 Elsevier GmbH. All rights reserved..
BACKGROUND: The heme oxygenase (HO) system plays a significant role in neuroprotection and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 and HO-2, regulates cellular redox balance. HO-1, an antioxidant defense enzyme, is highlighted due to its association with depression, characterized by heightened neuroinflammation and impaired oxidative stress responses.
METHODOLOGY: We observed the pathophysiology of HO-1 and phytochemicals as its modulator. We explored Science Direct, Scopus, and PubMed for a comprehensive literature review. Bibliometric and temporal trend analysis were done using VOSviewer.
RESULTS: Several phytochemicals can potentially alleviate neuroinflammation and oxidative stress-induced depressive symptoms. These effects result from inhibiting the MAPK and NK-κB pathways - both implicated in the overproduction of pro-inflammatory factors - and from the upregulation of HO-1 expression mediated by Nrf2. Bibliometric and temporal trend analysis further validates these associations.
CONCLUSION: In summary, our findings suggest that antidepressant agents can mitigate neuroinflammation and depressive disorder pathogenesis via the upregulation of HO-1 expression. These agents suppress pro-inflammatory mediators and depressive-like symptoms, demonstrating that HO-1 plays a significant role in the neuroinflammatory process and the development of depression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:127 |
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| Enthalten in: |
Phytomedicine : international journal of phytotherapy and phytopharmacology - 127(2024) vom: 26. März, Seite 155466 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Jiao [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 26.03.2024 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.phymed.2024.155466 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369514920 |
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| 100 | 1 | |a Wang, Jiao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exploring the pathophysiological influence of heme oxygenase-1 on neuroinflammation and depression |b A study of phytotherapeutic-based modulation |
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| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier GmbH. All rights reserved. | ||
| 520 | |a BACKGROUND: The heme oxygenase (HO) system plays a significant role in neuroprotection and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 and HO-2, regulates cellular redox balance. HO-1, an antioxidant defense enzyme, is highlighted due to its association with depression, characterized by heightened neuroinflammation and impaired oxidative stress responses | ||
| 520 | |a METHODOLOGY: We observed the pathophysiology of HO-1 and phytochemicals as its modulator. We explored Science Direct, Scopus, and PubMed for a comprehensive literature review. Bibliometric and temporal trend analysis were done using VOSviewer | ||
| 520 | |a RESULTS: Several phytochemicals can potentially alleviate neuroinflammation and oxidative stress-induced depressive symptoms. These effects result from inhibiting the MAPK and NK-κB pathways - both implicated in the overproduction of pro-inflammatory factors - and from the upregulation of HO-1 expression mediated by Nrf2. Bibliometric and temporal trend analysis further validates these associations | ||
| 520 | |a CONCLUSION: In summary, our findings suggest that antidepressant agents can mitigate neuroinflammation and depressive disorder pathogenesis via the upregulation of HO-1 expression. These agents suppress pro-inflammatory mediators and depressive-like symptoms, demonstrating that HO-1 plays a significant role in the neuroinflammatory process and the development of depression | ||
| 650 | 4 | |a Review | |
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| 650 | 4 | |a Depression | |
| 650 | 4 | |a Heme oxygenase | |
| 650 | 4 | |a Neuroinflammation | |
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| 700 | 1 | |a Rana, Tarapati |e verfasserin |4 aut | |
| 700 | 1 | |a Sehgal, Aayush |e verfasserin |4 aut | |
| 700 | 1 | |a Wal, Pranay |e verfasserin |4 aut | |
| 700 | 1 | |a Saxena, Bhagawati |e verfasserin |4 aut | |
| 700 | 1 | |a Yadav, Shivam |e verfasserin |4 aut | |
| 700 | 1 | |a Mohan, Syam |e verfasserin |4 aut | |
| 700 | 1 | |a Anwer, Md Khalid |e verfasserin |4 aut | |
| 700 | 1 | |a Chigurupati, Sridevi |e verfasserin |4 aut | |
| 700 | 1 | |a Zaheer, Imran |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Bairong |e verfasserin |4 aut | |
| 700 | 1 | |a Singla, Rajeev K |e verfasserin |4 aut | |
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