Preparation of calcium phosphate ion clusters through atomization method for biomimetic mineralization of enamel
© 2024 Wiley Periodicals LLC..
Dental enamel is a mineralized extracellular matrix, and enamel defect is a common oral disease. However, the self-repair capacity of enamel is limited due to the absence of cellular components and organic matter. Efficacy of biomimetic enamel mineralization using calcium phosphate ion clusters (CPICs), is an effective method to compensate for the limited self-healing ability of fully developed enamel. Preparing and stabilizing CPICs presents a significant challenge, as the addition of certain stabilizers can diminish the mechanical properties or biosafety of mineralized enamel. To efficiently and safely repair enamel damage, this study quickly prepared CPICs without stabilizers using the atomization method. The formed CPICs were evenly distributed on the enamel surface, prompting directional growth and transformation of hydroxyapatite (HA) crystals. The study revealed that the mended enamel displayed comparable morphology, chemical composition, hardness, and mechanical properties to those of the original enamel. The approach of repairing dental enamel by utilizing ultrasonic nebulization of CPICs is highly efficient and safe, therefore indicating great promise.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of biomedical materials research. Part A - (2024) vom: 10. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dong, Haide [VerfasserIn] |
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| Links: |
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| Themen: |
Amorphous calcium phosphate |
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| Anmerkungen: |
Date Revised 10.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/jbm.a.37706 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Dental enamel is a mineralized extracellular matrix, and enamel defect is a common oral disease. However, the self-repair capacity of enamel is limited due to the absence of cellular components and organic matter. Efficacy of biomimetic enamel mineralization using calcium phosphate ion clusters (CPICs), is an effective method to compensate for the limited self-healing ability of fully developed enamel. Preparing and stabilizing CPICs presents a significant challenge, as the addition of certain stabilizers can diminish the mechanical properties or biosafety of mineralized enamel. To efficiently and safely repair enamel damage, this study quickly prepared CPICs without stabilizers using the atomization method. The formed CPICs were evenly distributed on the enamel surface, prompting directional growth and transformation of hydroxyapatite (HA) crystals. The study revealed that the mended enamel displayed comparable morphology, chemical composition, hardness, and mechanical properties to those of the original enamel. The approach of repairing dental enamel by utilizing ultrasonic nebulization of CPICs is highly efficient and safe, therefore indicating great promise | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a biomimetic mineralization | |
| 650 | 4 | |a enamel repair | |
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| 700 | 1 | |a Zhu, Chen |e verfasserin |4 aut | |
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| 700 | 1 | |a Liu, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Quanfu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Weihu |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Kaiyong |e verfasserin |4 aut | |
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