Effects of short-term preoperative intranasal dexmedetomidine plus conventional treatment on delirium following cardiac surgery in patients with sleep disorders
© 2024. The Author(s)..
STUDY OBJECTIVES: To assess whether preoperative dexmedetomidine (DEX) nasal drips combined with conventional treatment could mitigate the occurrence of postoperative delirium (POD).
DESIGN: A prospective randomised controlled study.
SETTING: The cardiac surgery intensive care unit (CSICU) and patient hospitalisation ward at a university hospital.
PARTICIPANTS: A total of 100 patients (aged ≥60 years) undergoing cardiac surgery at a university hospital between 7 January 2022, and 30 November 2022 met the eligibility criteria and were included in the study.
INTERVENTIONS: Patients with sleep disorders (Pittsburgh Sleep Quality Index ≥8) were divided into two groups: Group A (the placebo group, n=50), receiving a short-term preoperative placebo combined with conventional treatment and Group B (the DEX group, n=50), receiving short-term preoperative DEX combined with conventional treatment.
MEASUREMENTS AND RESULTS: The Confusion Assessment Method for the ICU (CAM-ICU) was used for POD assessment in the CSICU, while the CAM was employed to assess delirium in the patient ward. Group B demonstrated a reduced incidence of POD compared to Group A (12% vs. 30%, odds ratio: 0.318, 95% confidence interval: 0.112-0.905, p=0.027).
CONCLUSION: The combined treatment involving DEX demonstrated a decreased incidence of POD in elderly individuals with sleep disorders undergoing cardiac surgery compared to the placebo combination treatment.
TRIAL REGISTRATION: URL: www.chictr.org.cn with registration number ChiCTR 2100043968, registered on 06/03/2021.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Perioperative medicine (London, England) - 13(2024), 1 vom: 09. März, Seite 17 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fang, Jun [VerfasserIn] |
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| Links: |
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| Themen: |
Cognitive function |
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| Anmerkungen: |
Date Revised 12.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/s13741-024-00371-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369510054 |
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| 245 | 1 | 0 | |a Effects of short-term preoperative intranasal dexmedetomidine plus conventional treatment on delirium following cardiac surgery in patients with sleep disorders |
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| 500 | |a Date Revised 12.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a STUDY OBJECTIVES: To assess whether preoperative dexmedetomidine (DEX) nasal drips combined with conventional treatment could mitigate the occurrence of postoperative delirium (POD) | ||
| 520 | |a DESIGN: A prospective randomised controlled study | ||
| 520 | |a SETTING: The cardiac surgery intensive care unit (CSICU) and patient hospitalisation ward at a university hospital | ||
| 520 | |a PARTICIPANTS: A total of 100 patients (aged ≥60 years) undergoing cardiac surgery at a university hospital between 7 January 2022, and 30 November 2022 met the eligibility criteria and were included in the study | ||
| 520 | |a INTERVENTIONS: Patients with sleep disorders (Pittsburgh Sleep Quality Index ≥8) were divided into two groups: Group A (the placebo group, n=50), receiving a short-term preoperative placebo combined with conventional treatment and Group B (the DEX group, n=50), receiving short-term preoperative DEX combined with conventional treatment | ||
| 520 | |a MEASUREMENTS AND RESULTS: The Confusion Assessment Method for the ICU (CAM-ICU) was used for POD assessment in the CSICU, while the CAM was employed to assess delirium in the patient ward. Group B demonstrated a reduced incidence of POD compared to Group A (12% vs. 30%, odds ratio: 0.318, 95% confidence interval: 0.112-0.905, p=0.027) | ||
| 520 | |a CONCLUSION: The combined treatment involving DEX demonstrated a decreased incidence of POD in elderly individuals with sleep disorders undergoing cardiac surgery compared to the placebo combination treatment | ||
| 520 | |a TRIAL REGISTRATION: URL: www.chictr.org.cn with registration number ChiCTR 2100043968, registered on 06/03/2021 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cognitive function | |
| 650 | 4 | |a Dexmedetomidine | |
| 650 | 4 | |a Preoperative intervention | |
| 650 | 4 | |a Sleep disorders | |
| 700 | 1 | |a Yang, Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhai, Mingyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qiong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Yanhu |e verfasserin |4 aut | |
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