Modeling T2 high severe asthma using human induced pluripotent stem cells (hiPSC)
Copyright © 2024 SPLF. Published by Elsevier Masson SAS. All rights reserved..
Severe asthma patients with persistent airflow obstruction are characterized by functional obstruction due to mucus plugs containing mucins, fibrin, and eosinophil derived Charcot- Leyden crystals. The molecular mechanisms underlying this endotype are not clearly understood. Developing new models is crucial to respiratory research insofar as critical differences exist between human and rodent airway epithelium. We (and other teams) have shown that it is possible to reconstitute in vitro a complex and functional airway epithelium displaying all the features described in vivo from human-induced pluripotent stem cells (hiPSC). Our aim is to establish a human in vitro model of severe asthma that will recapitulate airway epithelium remodeling and mucus plugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Revue des maladies respiratoires - 41(2024), 4 vom: 08. Apr., Seite 289-293 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Modélisation de l’asthme sévère par la technologie des cellules humaines souches pluripotentes induites (hiPSC) |
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| Beteiligte Personen: |
Ahmed, E [VerfasserIn] |
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| Links: |
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| Themen: |
Asthme sévère |
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| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 15.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.rmr.2024.02.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Copyright © 2024 SPLF. Published by Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a Severe asthma patients with persistent airflow obstruction are characterized by functional obstruction due to mucus plugs containing mucins, fibrin, and eosinophil derived Charcot- Leyden crystals. The molecular mechanisms underlying this endotype are not clearly understood. Developing new models is crucial to respiratory research insofar as critical differences exist between human and rodent airway epithelium. We (and other teams) have shown that it is possible to reconstitute in vitro a complex and functional airway epithelium displaying all the features described in vivo from human-induced pluripotent stem cells (hiPSC). Our aim is to establish a human in vitro model of severe asthma that will recapitulate airway epithelium remodeling and mucus plugs | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Asthme sévère | |
| 650 | 4 | |a Bouchon muqueux | |
| 650 | 4 | |a Eosinophil | |
| 650 | 4 | |a Eosinophile | |
| 650 | 4 | |a Epithelium | |
| 650 | 4 | |a Epithélium | |
| 650 | 4 | |a Galectin-10 crystals | |
| 650 | 4 | |a Galectine 10 | |
| 650 | 4 | |a Mucus plugs | |
| 650 | 4 | |a Severe asthma | |
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| 700 | 1 | |a Foisset, F |e verfasserin |4 aut | |
| 700 | 1 | |a Bourdais, C |e verfasserin |4 aut | |
| 700 | 1 | |a Vanheerswynghels, M |e verfasserin |4 aut | |
| 700 | 1 | |a Petit, A |e verfasserin |4 aut | |
| 700 | 1 | |a Gamez, A S |e verfasserin |4 aut | |
| 700 | 1 | |a Gras, D |e verfasserin |4 aut | |
| 700 | 1 | |a Chanez, P |e verfasserin |4 aut | |
| 700 | 1 | |a de Vos, J |e verfasserin |4 aut | |
| 700 | 1 | |a Hammad, H |e verfasserin |4 aut | |
| 700 | 1 | |a Bourdin, A |e verfasserin |4 aut | |
| 700 | 1 | |a Lambrecht, B |e verfasserin |4 aut | |
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