Addition of single dose gemtuzumab ozogamicin to intensive induction chemotherapy in core-binding factor acute myeloid leukemia
Copyright © 2024 Elsevier Ltd. All rights reserved..
In a meta-analysis of 5 trials, the addition of gemtuzumab ozogamicin (GO) to intensive induction chemotherapy led to a survival benefit in patients with core-binding factor (CBF) acute myeloid leukemia (AML). Given the heterogeneous incorporation of GO in clinical trials, the ideal dose and schedule remains unclear. We conducted a single-center retrospective analysis to compare outcomes of patients with CBF-AML treated with intensive induction chemotherapy, with or without a single dose of GO 3 mg/m2, during induction only. We included 87 patients (GO=32, control=55). The composite complete remission (cCR) rate was higher in the control group (93%) compared to the GO group (82%) (p<0.001). The rate of measurable residual disease (MRD) negative cCR, by flow cytometry, was similar between both groups. There were no significant differences between the two groups in terms of toxicity. The 3-year relapse-free survival (RFS) for both groups was similar (71% vs 68%, p=0.5). The 3-year overall survival (OS) for the GO group was 68%, compared to 66% for the control group (p=0.9).In multivariable analysis, age and MRD positive status were risk factors for inferior outcomes. We find that survival of patients with CBF-AML is favorable in the real-world setting. The addition of single-dose GO, during induction, did not lead to a higher remission rate or survival benefit, when compared to intensive chemotherapy without GO. Further investigation into the incorporation of GO in the treatment algorithm for CBF-AML is needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:139 |
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| Enthalten in: |
Leukemia research - 139(2024) vom: 29. Apr., Seite 107467 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bourne, Garrett [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 26.03.2024 Date Revised 11.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.leukres.2024.107467 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a In a meta-analysis of 5 trials, the addition of gemtuzumab ozogamicin (GO) to intensive induction chemotherapy led to a survival benefit in patients with core-binding factor (CBF) acute myeloid leukemia (AML). Given the heterogeneous incorporation of GO in clinical trials, the ideal dose and schedule remains unclear. We conducted a single-center retrospective analysis to compare outcomes of patients with CBF-AML treated with intensive induction chemotherapy, with or without a single dose of GO 3 mg/m2, during induction only. We included 87 patients (GO=32, control=55). The composite complete remission (cCR) rate was higher in the control group (93%) compared to the GO group (82%) (p<0.001). The rate of measurable residual disease (MRD) negative cCR, by flow cytometry, was similar between both groups. There were no significant differences between the two groups in terms of toxicity. The 3-year relapse-free survival (RFS) for both groups was similar (71% vs 68%, p=0.5). The 3-year overall survival (OS) for the GO group was 68%, compared to 66% for the control group (p=0.9).In multivariable analysis, age and MRD positive status were risk factors for inferior outcomes. We find that survival of patients with CBF-AML is favorable in the real-world setting. The addition of single-dose GO, during induction, did not lead to a higher remission rate or survival benefit, when compared to intensive chemotherapy without GO. Further investigation into the incorporation of GO in the treatment algorithm for CBF-AML is needed | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute Myeloid Leukemia | |
| 650 | 4 | |a Core-Binding Factor | |
| 650 | 4 | |a Gemtuzumab Ozogamicin | |
| 650 | 4 | |a Intensive Chemotherapy | |
| 650 | 7 | |a Gemtuzumab |2 NLM | |
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| 650 | 7 | |a Cytarabine |2 NLM | |
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| 650 | 7 | |a Aminoglycosides |2 NLM | |
| 650 | 7 | |a Core Binding Factors |2 NLM | |
| 700 | 1 | |a Diebold, Kendall |e verfasserin |4 aut | |
| 700 | 1 | |a Espinoza-Gutarra, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Kadhimi, Zaid |e verfasserin |4 aut | |
| 700 | 1 | |a Bachiashvili, Kimo |e verfasserin |4 aut | |
| 700 | 1 | |a Rangaraju, Sravanti |e verfasserin |4 aut | |
| 700 | 1 | |a Vachhani, Pankit |e verfasserin |4 aut | |
| 700 | 1 | |a Bhatia, Ravi |e verfasserin |4 aut | |
| 700 | 1 | |a Jamy, Omer |e verfasserin |4 aut | |
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