Vitamin D and behavioral disorders in older adults : results from the CLIP study
Copyright © 2024. Published by Elsevier Masson SAS..
OBJECTIVES: Vitamin D is involved in brain health and function. Our objective was to determine whether vitamin D deficiency was associated with behavioral disorders in geriatric patients.
DESIGN: The observational cross-sectional CLIP (Cognition and LIPophilic vitamins) study. The report followed the STROBE statement.
SETTING: Geriatric acute care unit in a tertiary university hospital in France for 3 months at the end of winter and beginning of spring.
PARTICIPANTS: 272 patients ≥65 years consecutively hospitalized or seen in consultation.
MEASUREMENTS: Participants were separated into two groups according to vitamin D deficiency (i.e., serum 25-hydroxyvitamin D ≤25 nmol/L). Behavior was assessed using the reduced version of the Neuropsychiatric Inventory Scale (NPI-R) score and subscores. Age, sex, BMI, education level, comorbidities, MMSE and GDS scores, use psychoactive drugs and vitamin D supplements, and serum concentrations of calcium, parathyroid hormone, TSH and estimated glomerular filtration rate (eGFR) were used as potential confounders.
RESULTS: Participants with vitamin D deficiency (n = 78) had similar NPI-R score (17.4 ± 20.3 versus 17.2 ± 16.1, p = 0.92) but higher (i.e., worse) subscore of agitation and aggressiveness (2.0 ± 3.3 versus 1.2 ± 2.4, p = 0.02) and higher (i.e., worse) subscore of disinhibition (0.99 ± 2.98 versus 0.38 ± 1.42, p = 0.02) than those without vitamin D deficiency (n = 194). In multiple linear regressions, vitamin D deficiency was inversely associated with the subscore of agitation and aggressiveness (β = 1.37, p = 0.005) and with the subscore of disinhibition (β = 0.96, p = 0.008).
CONCLUSION: Vitamin D deficiency was associated with more severe subscores of agitation and aggressiveness and of disinhibition among older adults. This provides a scientific basis to test the efficacy of vitamin D supplementation on behavioral disorders in older patients with vitamin D deficiency.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
The journal of nutrition, health & aging - 28(2024), 4 vom: 08. März, Seite 100205 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gilbert, Lucie [VerfasserIn] |
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| Links: |
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| Themen: |
Behavior |
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| Anmerkungen: |
Date Revised 09.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jnha.2024.100205 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369499395 |
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| 100 | 1 | |a Gilbert, Lucie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vitamin D and behavioral disorders in older adults |b results from the CLIP study |
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| 500 | |a Date Revised 09.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024. Published by Elsevier Masson SAS. | ||
| 520 | |a OBJECTIVES: Vitamin D is involved in brain health and function. Our objective was to determine whether vitamin D deficiency was associated with behavioral disorders in geriatric patients | ||
| 520 | |a DESIGN: The observational cross-sectional CLIP (Cognition and LIPophilic vitamins) study. The report followed the STROBE statement | ||
| 520 | |a SETTING: Geriatric acute care unit in a tertiary university hospital in France for 3 months at the end of winter and beginning of spring | ||
| 520 | |a PARTICIPANTS: 272 patients ≥65 years consecutively hospitalized or seen in consultation | ||
| 520 | |a MEASUREMENTS: Participants were separated into two groups according to vitamin D deficiency (i.e., serum 25-hydroxyvitamin D ≤25 nmol/L). Behavior was assessed using the reduced version of the Neuropsychiatric Inventory Scale (NPI-R) score and subscores. Age, sex, BMI, education level, comorbidities, MMSE and GDS scores, use psychoactive drugs and vitamin D supplements, and serum concentrations of calcium, parathyroid hormone, TSH and estimated glomerular filtration rate (eGFR) were used as potential confounders | ||
| 520 | |a RESULTS: Participants with vitamin D deficiency (n = 78) had similar NPI-R score (17.4 ± 20.3 versus 17.2 ± 16.1, p = 0.92) but higher (i.e., worse) subscore of agitation and aggressiveness (2.0 ± 3.3 versus 1.2 ± 2.4, p = 0.02) and higher (i.e., worse) subscore of disinhibition (0.99 ± 2.98 versus 0.38 ± 1.42, p = 0.02) than those without vitamin D deficiency (n = 194). In multiple linear regressions, vitamin D deficiency was inversely associated with the subscore of agitation and aggressiveness (β = 1.37, p = 0.005) and with the subscore of disinhibition (β = 0.96, p = 0.008) | ||
| 520 | |a CONCLUSION: Vitamin D deficiency was associated with more severe subscores of agitation and aggressiveness and of disinhibition among older adults. This provides a scientific basis to test the efficacy of vitamin D supplementation on behavioral disorders in older patients with vitamin D deficiency | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Behavior | |
| 650 | 4 | |a Neurocognition | |
| 650 | 4 | |a Neuroendocrinology | |
| 650 | 4 | |a Older adults | |
| 650 | 4 | |a Vitamin D | |
| 700 | 1 | |a Bourgeais, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Karras, Spyridon N |e verfasserin |4 aut | |
| 700 | 1 | |a Gezen-Ak, Duygu |e verfasserin |4 aut | |
| 700 | 1 | |a Dursun, Erdinç |e verfasserin |4 aut | |
| 700 | 1 | |a Annweiler, Cédric |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:28 |g year:2024 |g number:4 |g day:08 |g month:03 |g pages:100205 |
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