Afferent renal denervation attenuates sympathetic over activation from the paraventricular nucleus in spontaneously hypertensive rats
© The Author(s) 2024. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
The effectiveness of Renal Denervation (RDN) in reducing blood pressure and systemic sympathetic activity in hypertensive patients has been established. However, the underlying central mechanism remains unknown. This study aimed to investigate the role of RDN in regulating cardiovascular function via the central Renin-Angiotensin System (RAS) pathway. Ten-week-old Spontaneously Hypertensive Rats (SHR) were subjected to Selective Afferent Renal Denervation (ADN) using capsaicin solution. We hypothesized that ADN would effectively reduce blood pressure and rebalance the RAS component of PVN in SHR. The experimental results show that ADN group exhibited significantly lower blood pressure, reduced systemic sympathetic activity, decreased chronic neuronal activation marker C-FOS expression in the paraventricular nucleus of hypothalamus (PVN), and improved arterial baroreflex function, compared with the Sham group. Furthermore, ACE and AT1 protein expression was reduced while ACE2 and MAS protein expression was increased in the PVN of SHR after ADN. These findings suggest that RDN may exert these beneficial effects through modulating the central RAS pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of hypertension - (2024) vom: 09. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Kun-Hui [VerfasserIn] |
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| Links: |
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| Themen: |
Afferent renal denervation |
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| Anmerkungen: |
Date Revised 09.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1093/ajh/hpae027 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369496671 |
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| 100 | 1 | |a Li, Kun-Hui |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Afferent renal denervation attenuates sympathetic over activation from the paraventricular nucleus in spontaneously hypertensive rats |
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| 520 | |a © The Author(s) 2024. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a The effectiveness of Renal Denervation (RDN) in reducing blood pressure and systemic sympathetic activity in hypertensive patients has been established. However, the underlying central mechanism remains unknown. This study aimed to investigate the role of RDN in regulating cardiovascular function via the central Renin-Angiotensin System (RAS) pathway. Ten-week-old Spontaneously Hypertensive Rats (SHR) were subjected to Selective Afferent Renal Denervation (ADN) using capsaicin solution. We hypothesized that ADN would effectively reduce blood pressure and rebalance the RAS component of PVN in SHR. The experimental results show that ADN group exhibited significantly lower blood pressure, reduced systemic sympathetic activity, decreased chronic neuronal activation marker C-FOS expression in the paraventricular nucleus of hypothalamus (PVN), and improved arterial baroreflex function, compared with the Sham group. Furthermore, ACE and AT1 protein expression was reduced while ACE2 and MAS protein expression was increased in the PVN of SHR after ADN. These findings suggest that RDN may exert these beneficial effects through modulating the central RAS pathway | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a afferent renal denervation | |
| 650 | 4 | |a baroreflex sensitivity | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a renin-angiotensin system | |
| 650 | 4 | |a sympathetic nerve activity | |
| 700 | 1 | |a Lin, Jie-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Si-Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Min-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yi-Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Meng-Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Pan-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Jin-Zi |e verfasserin |4 aut | |
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