PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling
Copyright © 2024 Elsevier Ltd. All rights reserved..
Fine particulate matter (PM2.5) has been linked to increased severity and incidence of airway diseases, especially chronic obstructive pulmonary disease (COPD) and asthma. Airway remodeling is an important event in both COPD and asthma, and airway smooth muscle cells (ASMCs) are key cells which directly involved in airway remodeling. However, it was unclear how PM2.5 affected ASMCs. This study investigates the effects of PM2.5 on airway smooth muscle and its mechanism. We first showed that inhaled particulate matter was distributed in the airway smooth muscle bundle, combined with increased airway smooth muscle bundle and collagen deposition in vivo. Then, we demonstrated that PM2.5 induced up-regulation of collagen-I and alpha-smooth muscle actin (α-SMA) expression in rat and human ASMCs in vitro. Next, we found PM2.5 led to rat and human ASMCs senescence and exhibited senescence-associated secretory phenotype (SASP) by autophagy-induced GATA4/TRAF6/NF-κB signaling, which contributed to collagen-I and α-SMA synthesis as well as airway smooth muscle remodeling. Together, our results provided evidence that SASP induced by PM2.5 in airway smooth muscle cells prompted airway remodeling.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:347 |
|---|---|
| Enthalten in: |
Environmental pollution (Barking, Essex : 1987) - 347(2024) vom: 15. Apr., Seite 123674 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cheng, Pei-Pei [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Airway smooth muscle |
|---|
| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.envpol.2024.123674 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369482549 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369482549 | ||
| 003 | DE-627 | ||
| 005 | 20240408232616.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240309s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.envpol.2024.123674 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1369.xml |
| 035 | |a (DE-627)NLM369482549 | ||
| 035 | |a (NLM)38458517 | ||
| 035 | |a (PII)S0269-7491(24)00388-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cheng, Pei-Pei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.04.2024 | ||
| 500 | |a Date Revised 08.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Fine particulate matter (PM2.5) has been linked to increased severity and incidence of airway diseases, especially chronic obstructive pulmonary disease (COPD) and asthma. Airway remodeling is an important event in both COPD and asthma, and airway smooth muscle cells (ASMCs) are key cells which directly involved in airway remodeling. However, it was unclear how PM2.5 affected ASMCs. This study investigates the effects of PM2.5 on airway smooth muscle and its mechanism. We first showed that inhaled particulate matter was distributed in the airway smooth muscle bundle, combined with increased airway smooth muscle bundle and collagen deposition in vivo. Then, we demonstrated that PM2.5 induced up-regulation of collagen-I and alpha-smooth muscle actin (α-SMA) expression in rat and human ASMCs in vitro. Next, we found PM2.5 led to rat and human ASMCs senescence and exhibited senescence-associated secretory phenotype (SASP) by autophagy-induced GATA4/TRAF6/NF-κB signaling, which contributed to collagen-I and α-SMA synthesis as well as airway smooth muscle remodeling. Together, our results provided evidence that SASP induced by PM2.5 in airway smooth muscle cells prompted airway remodeling | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Airway smooth muscle | |
| 650 | 4 | |a PM2.5 | |
| 650 | 4 | |a Remodeling | |
| 650 | 4 | |a SASP | |
| 650 | 7 | |a Collagen Type I |2 NLM | |
| 650 | 7 | |a Particulate Matter |2 NLM | |
| 700 | 1 | |a Yu, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Shuai-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Zi-Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Shi-He |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Xiao-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Ya-Ya |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Li-Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Lin-Jie |e verfasserin |4 aut | |
| 700 | 1 | |a He, Xin-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Xiong, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaorong |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Wan-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Hong |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Environmental pollution (Barking, Essex : 1987) |d 1987 |g 347(2024) vom: 15. Apr., Seite 123674 |w (DE-627)NLM087741504 |x 1873-6424 |7 nnns |
| 773 | 1 | 8 | |g volume:347 |g year:2024 |g day:15 |g month:04 |g pages:123674 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.envpol.2024.123674 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 347 |j 2024 |b 15 |c 04 |h 123674 | ||