Association of serum concentrations of remnant cholesterol with incident cardiovascular disease in patients with rheumatoid arthritis : A real-world data from 2001 to 2022
Copyright © 2024 Elsevier B.V. All rights reserved..
BACKGROUND: Remnant cholesterol (RC) promotes cardiovascular disease (CVD) in the general population, but its role among rheumatoid arthritis (RA) patients remains unknown. We aimed to investigate circulating RC levels associated with incident CVD among Chinese patients with RA.
METHODS: A total of 1018 RA patients free of baseline CVD were included and followed up in a prospective RA CVD cohort from 2001 to 2022. Fasting serum levels of triglycerides, total cholesterol (TC), low-density (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured, while RC and Non-HDL-C levels were calculated. The primary exposure was RC levels. A LASSO Cox model was used to select covariates. The Fine-Gray competing risk model was used to estimate hazard ratios (HRs).
RESULTS: RA patients had a mean age of 53.9 years, and 802 (78.8%) were females. After a median follow-up of 5.54 years, 131 patients developed CVD with an incidence rate of 21.6 per 1000 person-years. Continuous and quartile-categorized RC levels were associated with incident CVD before and after multivariate adjustment and Bonferroni correction (all P < 0.001). There were no robust associations of other lipids with incident CVD. The fully adjusted HRs for RC were 2.30 (95% CI 1.58-3.35) per 1 mmol/L increase, and 2.40 (1.36-4.25) and 2.81 (1.60-4.94) for patients in the 3rd and 4th versus the 1st quartile, respectively.
CONCLUSIONS: Circulating RC levels are positively associated with incident CVD among Chinese RA patients independent of known risk factors, implying its clinically preferable use for improving the stratification of CVD risk in RA patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
International journal of cardiology - (2024) vom: 07. März, Seite 131947 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zou, Yao-Wei [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular disease |
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| Anmerkungen: |
Date Revised 19.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.ijcard.2024.131947 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369481208 |
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| 041 | |a eng | ||
| 100 | 1 | |a Zou, Yao-Wei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of serum concentrations of remnant cholesterol with incident cardiovascular disease in patients with rheumatoid arthritis |b A real-world data from 2001 to 2022 |
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| 500 | |a Date Revised 19.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Remnant cholesterol (RC) promotes cardiovascular disease (CVD) in the general population, but its role among rheumatoid arthritis (RA) patients remains unknown. We aimed to investigate circulating RC levels associated with incident CVD among Chinese patients with RA | ||
| 520 | |a METHODS: A total of 1018 RA patients free of baseline CVD were included and followed up in a prospective RA CVD cohort from 2001 to 2022. Fasting serum levels of triglycerides, total cholesterol (TC), low-density (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured, while RC and Non-HDL-C levels were calculated. The primary exposure was RC levels. A LASSO Cox model was used to select covariates. The Fine-Gray competing risk model was used to estimate hazard ratios (HRs) | ||
| 520 | |a RESULTS: RA patients had a mean age of 53.9 years, and 802 (78.8%) were females. After a median follow-up of 5.54 years, 131 patients developed CVD with an incidence rate of 21.6 per 1000 person-years. Continuous and quartile-categorized RC levels were associated with incident CVD before and after multivariate adjustment and Bonferroni correction (all P < 0.001). There were no robust associations of other lipids with incident CVD. The fully adjusted HRs for RC were 2.30 (95% CI 1.58-3.35) per 1 mmol/L increase, and 2.40 (1.36-4.25) and 2.81 (1.60-4.94) for patients in the 3rd and 4th versus the 1st quartile, respectively | ||
| 520 | |a CONCLUSIONS: Circulating RC levels are positively associated with incident CVD among Chinese RA patients independent of known risk factors, implying its clinically preferable use for improving the stratification of CVD risk in RA patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiovascular disease | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Lipid profile | |
| 650 | 4 | |a Remnant cholesterol | |
| 650 | 4 | |a Rheumatoid arthritis | |
| 700 | 1 | |a Wu, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Qian-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Jian-Da |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Jian-Zi |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Pei-Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Hu-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Jing-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Mo, Ying-Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Lie |e verfasserin |4 aut | |
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