Mobile phone use and brain tumour risk - COSMOS, a prospective cohort study
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: Each new generation of mobile phone technology has triggered discussions about potential carcinogenicity from exposure to radiofrequency electromagnetic fields (RF-EMF). Available evidence has been insufficient to conclude about long-term and heavy mobile phone use, limited by differential recall and selection bias, or crude exposure assessment. The Cohort Study on Mobile Phones and Health (COSMOS) was specifically designed to overcome these shortcomings.
METHODS: We recruited participants in Denmark, Finland, the Netherlands, Sweden, and the UK 2007-2012. The baseline questionnaire assessed lifetime history of mobile phone use. Participants were followed through population-based cancer registers to identify glioma, meningioma, and acoustic neuroma cases during follow-up. Non-differential exposure misclassification was reduced by adjusting estimates of mobile phone call-time through regression calibration methods based on self-reported data and objective operator-recorded information at baseline. Hazard ratios (HR) and 95% confidence intervals (CI) for glioma, meningioma, and acoustic neuroma in relation to lifetime history of mobile phone use were estimated with Cox regression models with attained age as the underlying time-scale, adjusted for country, sex, educational level, and marital status.
RESULTS: 264,574 participants accrued 1,836,479 person-years. During a median follow-up of 7.12 years, 149 glioma, 89 meningioma, and 29 incident cases of acoustic neuroma were diagnosed. The adjusted HR per 100 regression-calibrated cumulative hours of mobile phone call-time was 1.00 (95 % CI 0.98-1.02) for glioma, 1.01 (95 % CI 0.96-1.06) for meningioma, and 1.02 (95 % CI 0.99-1.06) for acoustic neuroma. For glioma, the HR for ≥ 1908 regression-calibrated cumulative hours (90th percentile cut-point) was 1.07 (95 % CI 0.62-1.86). Over 15 years of mobile phone use was not associated with an increased tumour risk; for glioma the HR was 0.97 (95 % CI 0.62-1.52).
CONCLUSIONS: Our findings suggest that the cumulative amount of mobile phone use is not associated with the risk of developing glioma, meningioma, or acoustic neuroma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:185 |
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| Enthalten in: |
Environment international - 185(2024) vom: 17. März, Seite 108552 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Feychting, Maria [VerfasserIn] |
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| Links: |
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| Themen: |
Brain neoplasms |
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| Anmerkungen: |
Date Completed 26.03.2024 Date Revised 20.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.envint.2024.108552 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369478509 |
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| 245 | 1 | 0 | |a Mobile phone use and brain tumour risk - COSMOS, a prospective cohort study |
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| 500 | |a Date Revised 20.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: Each new generation of mobile phone technology has triggered discussions about potential carcinogenicity from exposure to radiofrequency electromagnetic fields (RF-EMF). Available evidence has been insufficient to conclude about long-term and heavy mobile phone use, limited by differential recall and selection bias, or crude exposure assessment. The Cohort Study on Mobile Phones and Health (COSMOS) was specifically designed to overcome these shortcomings | ||
| 520 | |a METHODS: We recruited participants in Denmark, Finland, the Netherlands, Sweden, and the UK 2007-2012. The baseline questionnaire assessed lifetime history of mobile phone use. Participants were followed through population-based cancer registers to identify glioma, meningioma, and acoustic neuroma cases during follow-up. Non-differential exposure misclassification was reduced by adjusting estimates of mobile phone call-time through regression calibration methods based on self-reported data and objective operator-recorded information at baseline. Hazard ratios (HR) and 95% confidence intervals (CI) for glioma, meningioma, and acoustic neuroma in relation to lifetime history of mobile phone use were estimated with Cox regression models with attained age as the underlying time-scale, adjusted for country, sex, educational level, and marital status | ||
| 520 | |a RESULTS: 264,574 participants accrued 1,836,479 person-years. During a median follow-up of 7.12 years, 149 glioma, 89 meningioma, and 29 incident cases of acoustic neuroma were diagnosed. The adjusted HR per 100 regression-calibrated cumulative hours of mobile phone call-time was 1.00 (95 % CI 0.98-1.02) for glioma, 1.01 (95 % CI 0.96-1.06) for meningioma, and 1.02 (95 % CI 0.99-1.06) for acoustic neuroma. For glioma, the HR for ≥ 1908 regression-calibrated cumulative hours (90th percentile cut-point) was 1.07 (95 % CI 0.62-1.86). Over 15 years of mobile phone use was not associated with an increased tumour risk; for glioma the HR was 0.97 (95 % CI 0.62-1.52) | ||
| 520 | |a CONCLUSIONS: Our findings suggest that the cumulative amount of mobile phone use is not associated with the risk of developing glioma, meningioma, or acoustic neuroma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Brain neoplasms | |
| 650 | 4 | |a Cell phones | |
| 650 | 4 | |a Cohort study | |
| 650 | 4 | |a Electromagnetic fields | |
| 650 | 4 | |a Non-ionizing radiation | |
| 650 | 4 | |a Radiofrequency fields | |
| 700 | 1 | |a Schüz, Joachim |e verfasserin |4 aut | |
| 700 | 1 | |a Toledano, Mireille B |e verfasserin |4 aut | |
| 700 | 1 | |a Vermeulen, Roel |e verfasserin |4 aut | |
| 700 | 1 | |a Auvinen, Anssi |e verfasserin |4 aut | |
| 700 | 1 | |a Harbo Poulsen, Aslak |e verfasserin |4 aut | |
| 700 | 1 | |a Deltour, Isabelle |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Rachel B |e verfasserin |4 aut | |
| 700 | 1 | |a Heller, Joel |e verfasserin |4 aut | |
| 700 | 1 | |a Kromhout, Hans |e verfasserin |4 aut | |
| 700 | 1 | |a Huss, Anke |e verfasserin |4 aut | |
| 700 | 1 | |a Johansen, Christoffer |e verfasserin |4 aut | |
| 700 | 1 | |a Tettamanti, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Elliott, Paul |e verfasserin |4 aut | |
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