Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling
AJCR Copyright © 2024..
Prostate cancer (PCa), especially castration-resistant PCa, is a common and fatal disease. Anillin (ANLN) is an actin-binding protein that is involved in various malignancies, including PCa. However, the regulatory mechanism of ANLN in PCa remains unclear. Exploring the role of ANLN in PCa development and discovering novel therapeutic targets are crucial for PCa therapy. In the current work, we discovered that ANLN expression was considerably elevated in PCa tissues and cell lines when compared to nearby noncancerous prostate tissues and normal prostate epithelial cells. ANLN was associated with more advanced T stage, N stage, higher Gleason score, and prostate-specific antigen (PSA) level. In addition, we discovered that overexpression of ANLN promoted PCa cell proliferation, migration, and invasion in vitro and in vivo. Mechanistically, we performed RNA-seq to identify the regulatory influence of ANLN on the MAPK signal pathway. Furthermore, a favorable association between ANLN expression and IGF2BP1 expression was identified. The tumor-suppressive impact of ANLN downregulation on PCa cell growth was partially reversed by overexpressing IGF2BP1. Meanwhile, we discovered that ANLN can stabilize the proto-oncogene c-Myc and activate the MAPK signaling pathway through IGF2BP1. These findings indicate that ANLN could be a potential therapeutic target in PCa.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
American journal of cancer research - 14(2024), 2 vom: 29., Seite 490-506 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Jinke [VerfasserIn] |
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| Themen: |
ANLN |
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| Anmerkungen: |
Date Revised 09.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369451619 |
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| 245 | 1 | 0 | |a Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling |
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| 520 | |a AJCR Copyright © 2024. | ||
| 520 | |a Prostate cancer (PCa), especially castration-resistant PCa, is a common and fatal disease. Anillin (ANLN) is an actin-binding protein that is involved in various malignancies, including PCa. However, the regulatory mechanism of ANLN in PCa remains unclear. Exploring the role of ANLN in PCa development and discovering novel therapeutic targets are crucial for PCa therapy. In the current work, we discovered that ANLN expression was considerably elevated in PCa tissues and cell lines when compared to nearby noncancerous prostate tissues and normal prostate epithelial cells. ANLN was associated with more advanced T stage, N stage, higher Gleason score, and prostate-specific antigen (PSA) level. In addition, we discovered that overexpression of ANLN promoted PCa cell proliferation, migration, and invasion in vitro and in vivo. Mechanistically, we performed RNA-seq to identify the regulatory influence of ANLN on the MAPK signal pathway. Furthermore, a favorable association between ANLN expression and IGF2BP1 expression was identified. The tumor-suppressive impact of ANLN downregulation on PCa cell growth was partially reversed by overexpressing IGF2BP1. Meanwhile, we discovered that ANLN can stabilize the proto-oncogene c-Myc and activate the MAPK signaling pathway through IGF2BP1. These findings indicate that ANLN could be a potential therapeutic target in PCa | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ANLN | |
| 650 | 4 | |a IGF2BP1 | |
| 650 | 4 | |a MAPK | |
| 650 | 4 | |a c-Myc | |
| 650 | 4 | |a metastasis | |
| 650 | 4 | |a proliferation | |
| 650 | 4 | |a prostate cancer | |
| 700 | 1 | |a Wang, Shiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Cong |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Ziwei |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Dunsheng |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yufeng |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Xiaoming |e verfasserin |4 aut | |
| 700 | 1 | |a Chao, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Zhiming |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Guoxiong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Gang |e verfasserin |4 aut | |
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