Folate-producing bifidobacteria : metabolism, genetics, and relevance
© The Author(s) 2023..
Folate (the general term for all bioactive forms of vitamin B9) plays a crucial role in the evolutionary highly conserved one-carbon (1C) metabolism, a network including central reactions such as DNA and protein synthesis and methylation of macromolecules. Folate delivers 1C units, such as methyl and formyl, between reactants. Plants, algae, fungi, and many bacteria can naturally produce folate, whereas animals, including humans, must obtain folate from external sources. For humans, folate deficiency is, however, a widespread problem. Bifidobacteria constitute an important component of human and many animal microbiomes, providing various health advantages to the host, such as producing folate. This review focuses on bifidobacteria and folate metabolism and the current knowledge of the distribution of genes needed for complete folate biosynthesis across different bifidobacterial species. Biotechnologies based on folate-trophic probiotics aim to create fermented products enriched with folate or design probiotic supplements that can synthesize folate in the colon, improving overall health. Therefore, bifidobacteria (alone or in association with other microorganisms) may, in the future, contribute to reducing widespread folate deficiencies prevalent among vulnerable human population groups, such as older people, women at child-birth age, and people in low-income countries.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
|---|---|
| Enthalten in: |
Microbiome research reports - 3(2024), 1 vom: 06., Seite 11 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
D'Aimmo, Maria Rosaria [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Bifidobacteria |
|---|
| Anmerkungen: |
Date Revised 09.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.20517/mrr.2023.59 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369448154 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369448154 | ||
| 003 | DE-627 | ||
| 005 | 20240309232527.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240308s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.20517/mrr.2023.59 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1321.xml |
| 035 | |a (DE-627)NLM369448154 | ||
| 035 | |a (NLM)38455078 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a D'Aimmo, Maria Rosaria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Folate-producing bifidobacteria |b metabolism, genetics, and relevance |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 09.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2023. | ||
| 520 | |a Folate (the general term for all bioactive forms of vitamin B9) plays a crucial role in the evolutionary highly conserved one-carbon (1C) metabolism, a network including central reactions such as DNA and protein synthesis and methylation of macromolecules. Folate delivers 1C units, such as methyl and formyl, between reactants. Plants, algae, fungi, and many bacteria can naturally produce folate, whereas animals, including humans, must obtain folate from external sources. For humans, folate deficiency is, however, a widespread problem. Bifidobacteria constitute an important component of human and many animal microbiomes, providing various health advantages to the host, such as producing folate. This review focuses on bifidobacteria and folate metabolism and the current knowledge of the distribution of genes needed for complete folate biosynthesis across different bifidobacterial species. Biotechnologies based on folate-trophic probiotics aim to create fermented products enriched with folate or design probiotic supplements that can synthesize folate in the colon, improving overall health. Therefore, bifidobacteria (alone or in association with other microorganisms) may, in the future, contribute to reducing widespread folate deficiencies prevalent among vulnerable human population groups, such as older people, women at child-birth age, and people in low-income countries | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Bifidobacteria | |
| 650 | 4 | |a folate biofortification | |
| 650 | 4 | |a folate metabolism | |
| 650 | 4 | |a gut microbiota | |
| 700 | 1 | |a Satti, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Scarafile, Donatella |e verfasserin |4 aut | |
| 700 | 1 | |a Modesto, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Pascarelli, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Biagini, Simone Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Luiselli, Donata |e verfasserin |4 aut | |
| 700 | 1 | |a Mattarelli, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Andlid, Thomas |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Microbiome research reports |d 2021 |g 3(2024), 1 vom: 06., Seite 11 |w (DE-627)NLM363425225 |x 2771-5965 |7 nnns |
| 773 | 1 | 8 | |g volume:3 |g year:2024 |g number:1 |g day:06 |g pages:11 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.20517/mrr.2023.59 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 3 |j 2024 |e 1 |b 06 |h 11 | ||