MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery
© 2024. The Author(s)..
Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pre- and post-surgery non-fiberscopic miniBAL fluids were analysed for MUC5AC, MUC5B, IL-8, human neutrophil elastase, and neutrophils. All measured biomarkers increased after surgery. Perioperative MUC5AC-change showed a significant negative association with postoperative P/F ratio (p = 0.018), and a positive association with ICU stay (p = 0.027). In conclusion, development of lung injury after cardiac surgery and prolonged ICU stay are associated with an early increase of MUC5AC as detected in mini-BAL.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Respiratory research - 25(2024), 1 vom: 07. März, Seite 117 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Paassen, Judith [VerfasserIn] |
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| Links: |
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| Themen: |
ARDS |
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| Anmerkungen: |
Date Completed 11.03.2024 Date Revised 11.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12931-024-02747-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369442164 |
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| 245 | 1 | 0 | |a MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pre- and post-surgery non-fiberscopic miniBAL fluids were analysed for MUC5AC, MUC5B, IL-8, human neutrophil elastase, and neutrophils. All measured biomarkers increased after surgery. Perioperative MUC5AC-change showed a significant negative association with postoperative P/F ratio (p = 0.018), and a positive association with ICU stay (p = 0.027). In conclusion, development of lung injury after cardiac surgery and prolonged ICU stay are associated with an early increase of MUC5AC as detected in mini-BAL | ||
| 650 | 4 | |a Letter | |
| 650 | 4 | |a ARDS | |
| 650 | 4 | |a Cardiac surgery | |
| 650 | 4 | |a Intensive care | |
| 650 | 4 | |a Mucins | |
| 650 | 4 | |a Perioperative care | |
| 650 | 4 | |a Pulmonary biomarkers | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a MUC5AC protein, human |2 NLM | |
| 650 | 7 | |a Mucin 5AC |2 NLM | |
| 700 | 1 | |a Hiemstra, Pieter S |e verfasserin |4 aut | |
| 700 | 1 | |a van der Linden, Abraham C |e verfasserin |4 aut | |
| 700 | 1 | |a de Jonge, Evert |e verfasserin |4 aut | |
| 700 | 1 | |a Zwaginga, Jaap Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Klautz, Robert J M |e verfasserin |4 aut | |
| 700 | 1 | |a Arbous, M Sesmu |e verfasserin |4 aut | |
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