Genomic insights into Yak (Bos grunniens) adaptations for nutrient assimilation in high-altitudes
© 2024. The Author(s)..
High-altitude environments present formidable challenges for survival and reproduction, with organisms facing limited oxygen availability and scarce nutrient resources. The yak (Bos grunniens), indigenous to the Tibetan Plateau, has notably adapted to these extreme conditions. This study delves into the genomic basis of the yak's adaptation, focusing on the positive selection acting on genes involved in nutrient assimilation pathways. Employing techniques in comparative genomics and molecular evolutionary analyses, we selected genes in the yak that show signs of positive selection associated with nutrient metabolism, absorption, and transport. Our findings reveal specific genetic adaptations related to nutrient metabolism in harsh climatic conditions. Notably, genes involved in energy metabolism, oxygen transport, and thermoregulation exhibited signs of positive selection, suggesting their crucial role in the yak's successful colonization of high-altitude regions. The study also sheds light on the yak's immune system adaptations, emphasizing genes involved in response to various stresses prevalent at elevated altitudes. Insights into the yak's genomic makeup provide valuable information for understanding the broader implications of high-altitude adaptations in mammalian evolution. They may contribute to efforts in enhancing livestock resilience to environmental challenges.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Scientific reports - 14(2024), 1 vom: 07. März, Seite 5650 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ahmad, Hafiz Ishfaq [VerfasserIn] |
---|
Links: |
---|
Themen: |
Evolutionary mechanisms |
---|
Anmerkungen: |
Date Completed 11.03.2024 Date Revised 11.03.2024 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.1038/s41598-024-55712-3 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369437284 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369437284 | ||
003 | DE-627 | ||
005 | 20240311232608.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240308s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1038/s41598-024-55712-3 |2 doi | |
028 | 5 | 2 | |a pubmed24n1323.xml |
035 | |a (DE-627)NLM369437284 | ||
035 | |a (NLM)38453987 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Ahmad, Hafiz Ishfaq |e verfasserin |4 aut | |
245 | 1 | 0 | |a Genomic insights into Yak (Bos grunniens) adaptations for nutrient assimilation in high-altitudes |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 11.03.2024 | ||
500 | |a Date Revised 11.03.2024 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024. The Author(s). | ||
520 | |a High-altitude environments present formidable challenges for survival and reproduction, with organisms facing limited oxygen availability and scarce nutrient resources. The yak (Bos grunniens), indigenous to the Tibetan Plateau, has notably adapted to these extreme conditions. This study delves into the genomic basis of the yak's adaptation, focusing on the positive selection acting on genes involved in nutrient assimilation pathways. Employing techniques in comparative genomics and molecular evolutionary analyses, we selected genes in the yak that show signs of positive selection associated with nutrient metabolism, absorption, and transport. Our findings reveal specific genetic adaptations related to nutrient metabolism in harsh climatic conditions. Notably, genes involved in energy metabolism, oxygen transport, and thermoregulation exhibited signs of positive selection, suggesting their crucial role in the yak's successful colonization of high-altitude regions. The study also sheds light on the yak's immune system adaptations, emphasizing genes involved in response to various stresses prevalent at elevated altitudes. Insights into the yak's genomic makeup provide valuable information for understanding the broader implications of high-altitude adaptations in mammalian evolution. They may contribute to efforts in enhancing livestock resilience to environmental challenges | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Evolutionary mechanisms | |
650 | 4 | |a High-altitude adaptation | |
650 | 4 | |a Nutrient assimilation | |
650 | 4 | |a Positive selection | |
650 | 4 | |a Yak genomics | |
650 | 7 | |a Oxygen |2 NLM | |
650 | 7 | |a S88TT14065 |2 NLM | |
700 | 1 | |a Mahmood, Sammina |e verfasserin |4 aut | |
700 | 1 | |a Hassan, Mubashar |e verfasserin |4 aut | |
700 | 1 | |a Sajid, Muhammad |e verfasserin |4 aut | |
700 | 1 | |a Ahmed, Irfan |e verfasserin |4 aut | |
700 | 1 | |a Shokrollahi, Borhan |e verfasserin |4 aut | |
700 | 1 | |a Shahzad, Abid Hussain |e verfasserin |4 aut | |
700 | 1 | |a Abbas, Shaista |e verfasserin |4 aut | |
700 | 1 | |a Raza, Sanan |e verfasserin |4 aut | |
700 | 1 | |a Khan, Komal |e verfasserin |4 aut | |
700 | 1 | |a Muhammad, Sayyed Aun |e verfasserin |4 aut | |
700 | 1 | |a Fouad, Dalia |e verfasserin |4 aut | |
700 | 1 | |a Ataya, Farid S |e verfasserin |4 aut | |
700 | 1 | |a Li, Zhengtian |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Scientific reports |d 2011 |g 14(2024), 1 vom: 07. März, Seite 5650 |w (DE-627)NLM215703936 |x 2045-2322 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2024 |g number:1 |g day:07 |g month:03 |g pages:5650 |
856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-024-55712-3 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2024 |e 1 |b 07 |c 03 |h 5650 |