Evaluation of the toxic potential of Bisphenol-A glycidylmethacrylate (BisGMA) on the third instar larvae of transgenic Drosophila
© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissionsoup.com..
Introduction: In the present study the cytotoxic and genotoxic effects of Bisphenol-A glycidyl methacrylate (BisGMA) was studied on the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9.
Materials and methods: The concentration of BisGMA i.e. 0.005, 0.010, 0.015 and 0.020 M were established in diet and the larvae were allowed to feed on it for 24 h.
Results: A dose dependent significant increase in the activity of β-galactosidase was observed compared to control. A significant dose dependent tissue damage was observed in the larvae exposed to 0.010, 0.015 and 0.020 M of BisGMA compared to control. A dose dependent significant increase in the Oxidative stress markers was observed compared to control. BisGMA also exhibit significant DNA damaged in the third instar larvae of transgenic D. melanogaster (hsp70-lacZ)Bg9 at the doses of 0.010, 0.015 and 0.020 M compared to control.
Conclusion: BisGMA at 0.010, 0.015 and 0.020 M was found to be cytotoxic for the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg9.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Toxicology research - 13(2024), 2 vom: 15. März, Seite tfae026 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ibrahim, Nabeela [VerfasserIn] |
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| Links: |
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| Themen: |
Bisphenol-A-glycidylmethacrylate |
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| Anmerkungen: |
Date Revised 08.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1093/toxres/tfae026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369399455 |
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| 245 | 1 | 0 | |a Evaluation of the toxic potential of Bisphenol-A glycidylmethacrylate (BisGMA) on the third instar larvae of transgenic Drosophila |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a Introduction: In the present study the cytotoxic and genotoxic effects of Bisphenol-A glycidyl methacrylate (BisGMA) was studied on the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9 | ||
| 520 | |a Materials and methods: The concentration of BisGMA i.e. 0.005, 0.010, 0.015 and 0.020 M were established in diet and the larvae were allowed to feed on it for 24 h | ||
| 520 | |a Results: A dose dependent significant increase in the activity of β-galactosidase was observed compared to control. A significant dose dependent tissue damage was observed in the larvae exposed to 0.010, 0.015 and 0.020 M of BisGMA compared to control. A dose dependent significant increase in the Oxidative stress markers was observed compared to control. BisGMA also exhibit significant DNA damaged in the third instar larvae of transgenic D. melanogaster (hsp70-lacZ)Bg9 at the doses of 0.010, 0.015 and 0.020 M compared to control | ||
| 520 | |a Conclusion: BisGMA at 0.010, 0.015 and 0.020 M was found to be cytotoxic for the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg9 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Drosophila | |
| 650 | 4 | |a bisphenol-A-glycidylmethacrylate | |
| 650 | 4 | |a cytotoxicity | |
| 650 | 4 | |a genotoxicity | |
| 650 | 4 | |a oxidative stress | |
| 700 | 1 | |a Tariq, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Anjum, Arbab |e verfasserin |4 aut | |
| 700 | 1 | |a Varshney, Himanshi |e verfasserin |4 aut | |
| 700 | 1 | |a Gaur, Kajal |e verfasserin |4 aut | |
| 700 | 1 | |a Subhan, Iqra |e verfasserin |4 aut | |
| 700 | 1 | |a Jyoti, Smita |e verfasserin |4 aut | |
| 700 | 1 | |a Siddique, Yasir Hasan |e verfasserin |4 aut | |
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