A Comprehensive Review of Solriamfetol to Treat Excessive Daytime Sleepiness

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Purpose of Review: This is a comprehensive review of the literature regarding the use of Solriamfetol for excessive daytime sleepiness. It covers the background and current therapeutic approaches to treating excessive daytime sleepiness, the management of common comorbidities, and the existing evidence investigating the use of Solriamfetol for this purpose.

Recent Findings: Excessive daytime sleepiness leads to worse quality of life, a medical sequela and significant economic cost. There are multiple phenotypes of excessive daytime sleepiness depending on the comorbidity making treatment challenging. Due to the complexity of etiology there is not a cure for this ailment. Solriamfetol is a norepinephrine/dopamine dual reuptake antagonist that can be used to manage daytime sleepiness. Solriamfetol was first approved by the FDA in 2018 for use in excessive daytime sleepiness associated with obstructive sleep apnea and narcolepsy. Ongoing literature has proved this drug to be a safe and effective alternative pharmacotherapy.

Summary: Recent epidemiological data estimate up to one-third of the general adult population suffers from excessive daytime sleepiness. There is no cure to daytime somnolence and current pharmacotherapeutic regimens have worrisome side effect profiles. Solriamfetol is a new class of drug that offers a safe and effective alternative option for clinical providers treating excessive daytime sleepiness.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:54

Enthalten in:

Psychopharmacology bulletin - 54(2024), 1 vom: 04. März, Seite 65-86

Sprache:

Englisch

Beteiligte Personen:

Fuller, Mitchell C [VerfasserIn]
Carlson, Samuel [VerfasserIn]
Pysick, Haley [VerfasserIn]
Berry, Vince [VerfasserIn]
Tondryk, Andrew [VerfasserIn]
Swartz, Hayden [VerfasserIn]
Cornett, Elyse M [VerfasserIn]
Kaye, Adam M [VerfasserIn]
Viswanath, Omar [VerfasserIn]
Urits, Ivan [VerfasserIn]
Kaye, Alan D [VerfasserIn]

Themen:

47E5O17Y3R
939U7C91AI
Carbamates
Dopamine
Dopamine Antagonists
Journal Article
Narcolepsy
Norepinephrine
OSA
Obstructive sleep apnea
Phenylalanine
Review
Solriamfetol

Anmerkungen:

Date Completed 08.03.2024

Date Revised 08.03.2024

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM369392426