Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain : a prospective population-based screening study
© 2024. The Author(s)..
BACKGROUND: Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology test.
METHODS: We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in Spain. Schistosoma serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured questionnaire.
RESULTS: We included 388 adult males, mean age 43.5 years [Standard Deviation (SD) = 12.0, range: 18-76]. The median time since migration to the European Union was 17 [Interquartile range (IQR): 11-21] years. The most frequent country of origin was Senegal (N = 179, 46.1%). Of the 338, 147 (37.6%) tested positive for Schistosoma. Parasite eggs were present in the urine of only 1.3%. Nine genitourinary clinical items were significantly associated with positive Schistosoma serology results: pelvic pain (45.2%; OR = 1.57, 95% CI: 1.0-2.4), pain on ejaculation (14.5%; OR = 1.85, 95% CI: 1.0-3.5), dyspareunia (12.4%; OR = 2.45, 95% CI: 1.2-5.2), erectile dysfunction (9.5%; OR = 3.10, 95% CI: 1.3-7.6), self-reported episodes of infertility (32.1%; OR = 1.69, 95% CI: 1.0-2.8), haematuria (55.2%; OR = 2.37, 95% CI: 1.5-3.6), dysuria (52.1%; OR = 2.01, 95% CI: 1.3-3.1), undiagnosed syndromic STIs (5.4%), and orchitis (20.7%; OR = 1.81, 95% CI: 1.0-3.1). Clinical signs tended to cluster.
CONCLUSIONS: Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positive Schistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to chronic schistosomiasis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
|---|---|
| Enthalten in: |
Infectious diseases of poverty - 13(2024), 1 vom: 07. März, Seite 23 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Roure, Sílvia [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Chronic schistosomiasis |
|---|
| Anmerkungen: |
Date Completed 08.03.2024 Date Revised 09.03.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1186/s40249-024-01190-8 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36938797X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36938797X | ||
| 003 | DE-627 | ||
| 005 | 20240309232450.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240307s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s40249-024-01190-8 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1321.xml |
| 035 | |a (DE-627)NLM36938797X | ||
| 035 | |a (NLM)38449032 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Roure, Sílvia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain |b a prospective population-based screening study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.03.2024 | ||
| 500 | |a Date Revised 09.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND: Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology test | ||
| 520 | |a METHODS: We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in Spain. Schistosoma serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured questionnaire | ||
| 520 | |a RESULTS: We included 388 adult males, mean age 43.5 years [Standard Deviation (SD) = 12.0, range: 18-76]. The median time since migration to the European Union was 17 [Interquartile range (IQR): 11-21] years. The most frequent country of origin was Senegal (N = 179, 46.1%). Of the 338, 147 (37.6%) tested positive for Schistosoma. Parasite eggs were present in the urine of only 1.3%. Nine genitourinary clinical items were significantly associated with positive Schistosoma serology results: pelvic pain (45.2%; OR = 1.57, 95% CI: 1.0-2.4), pain on ejaculation (14.5%; OR = 1.85, 95% CI: 1.0-3.5), dyspareunia (12.4%; OR = 2.45, 95% CI: 1.2-5.2), erectile dysfunction (9.5%; OR = 3.10, 95% CI: 1.3-7.6), self-reported episodes of infertility (32.1%; OR = 1.69, 95% CI: 1.0-2.8), haematuria (55.2%; OR = 2.37, 95% CI: 1.5-3.6), dysuria (52.1%; OR = 2.01, 95% CI: 1.3-3.1), undiagnosed syndromic STIs (5.4%), and orchitis (20.7%; OR = 1.81, 95% CI: 1.0-3.1). Clinical signs tended to cluster | ||
| 520 | |a CONCLUSIONS: Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positive Schistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to chronic schistosomiasis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chronic schistosomiasis | |
| 650 | 4 | |a Long-term migrant | |
| 650 | 4 | |a Male genital schistosomiasis | |
| 650 | 4 | |a Schistosomiasis | |
| 650 | 4 | |a Urogenital schistosomiasis | |
| 700 | 1 | |a Vallès, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Quílez, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a López-Muñoz, Israel |e verfasserin |4 aut | |
| 700 | 1 | |a Chamorro, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Abad, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Valerio, Lluís |e verfasserin |4 aut | |
| 700 | 1 | |a Soldevila, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a España, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Hegazy, Alaa H A |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Rivas, Gema |e verfasserin |4 aut | |
| 700 | 1 | |a Gorriz, Ester |e verfasserin |4 aut | |
| 700 | 1 | |a Herena, Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Mário |e verfasserin |4 aut | |
| 700 | 1 | |a Miralles, Maria Carme |e verfasserin |4 aut | |
| 700 | 1 | |a Conde, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Montero-Alia, Juan José |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Pedregal, Elia |e verfasserin |4 aut | |
| 700 | 1 | |a Miranda-Sánchez, Jose |e verfasserin |4 aut | |
| 700 | 1 | |a Llibre, Josep M |e verfasserin |4 aut | |
| 700 | 1 | |a Isnard, Mar |e verfasserin |4 aut | |
| 700 | 1 | |a Bonet, Josep Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Estrada, Oriol |e verfasserin |4 aut | |
| 700 | 1 | |a Prat, Núria |e verfasserin |4 aut | |
| 700 | 1 | |a Clotet, Bonaventura |e verfasserin |4 aut | |
| 700 | 0 | |a Schisto-Stop study group |e verfasserin |4 aut | |
| 700 | 1 | |a Riera, Montserrat |e investigator |4 oth | |
| 700 | 1 | |a Rovira, Núria |e investigator |4 oth | |
| 700 | 1 | |a López, Ainhoa |e investigator |4 oth | |
| 700 | 1 | |a Segura, Mayra |e investigator |4 oth | |
| 700 | 1 | |a Escoda, Susana |e investigator |4 oth | |
| 700 | 1 | |a Villalaz-Gonzales, Janeth Karin |e investigator |4 oth | |
| 700 | 1 | |a Delgado, Maria Jesús |e investigator |4 oth | |
| 700 | 1 | |a Ferre-García, Iciar |e investigator |4 oth | |
| 700 | 1 | |a Santamaria, Sandra |e investigator |4 oth | |
| 700 | 1 | |a Matero, Marilen |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Infectious diseases of poverty |d 2012 |g 13(2024), 1 vom: 07. März, Seite 23 |w (DE-627)NLM229116728 |x 2049-9957 |7 nnns |
| 773 | 1 | 8 | |g volume:13 |g year:2024 |g number:1 |g day:07 |g month:03 |g pages:23 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s40249-024-01190-8 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 13 |j 2024 |e 1 |b 07 |c 03 |h 23 | ||