Cytokine storm in human monkeypox : A possible involvement of purinergic signaling
Copyright © 2024 Elsevier Ltd. All rights reserved..
Some evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence that consolidates the role of the cytokine storm in monkeypox infection and proposes a new hypothesis regarding the roles of purinergic signaling in this immune-mediated mechanism. We further suggested some purinergic signaling modulators to mitigate the deleterious and aggravating effects of immune dysregulation in human monkeypox virus infection by inhibiting P2X3, P2X7, P2Y2, and P2Y12, reducing inflammation, and activating A1 and A2A receptors to promote an anti-inflammatory response.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:177 |
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| Enthalten in: |
Cytokine - 177(2024) vom: 01. Apr., Seite 156560 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
da Silva, Gilnei Bruno [VerfasserIn] |
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| Links: |
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| Themen: |
Cytokine storm |
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| Anmerkungen: |
Date Completed 13.03.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cyto.2024.156560 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Some evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence that consolidates the role of the cytokine storm in monkeypox infection and proposes a new hypothesis regarding the roles of purinergic signaling in this immune-mediated mechanism. We further suggested some purinergic signaling modulators to mitigate the deleterious and aggravating effects of immune dysregulation in human monkeypox virus infection by inhibiting P2X3, P2X7, P2Y2, and P2Y12, reducing inflammation, and activating A1 and A2A receptors to promote an anti-inflammatory response | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cytokine storm | |
| 650 | 4 | |a Immune modulation | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Monkeypox | |
| 650 | 4 | |a Purinergic system | |
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| 700 | 1 | |a de Carvalho Braga, Geórgia |e verfasserin |4 aut | |
| 700 | 1 | |a Simões, Júlia Leão Batista |e verfasserin |4 aut | |
| 700 | 1 | |a Kempka, Aniela Pinto |e verfasserin |4 aut | |
| 700 | 1 | |a Bagatini, Margarete Dulce |e verfasserin |4 aut | |
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