Genomic characterization of SARS-CoV-2 in Guinea, West Africa

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SARS-CoV-2 has claimed several million lives since its emergence in late 2019. The ongoing evolution of the virus has resulted in the periodic emergence of new viral variants with distinct fitness advantages, including enhanced transmission and immune escape. While several SARS-CoV-2 variants of concern trace their origins back to the African continent-including Beta, Eta, and Omicron-most countries in Africa remain under-sampled in global genomic surveillance efforts. In an effort to begin filling these knowledge gaps, we conducted retrospective viral genomic surveillance in Guinea from October 2020 to August 2021. We found that SARS-CoV-2 clades 20A, 20B, and 20C dominated throughout 2020 until the coincident emergence of the Alpha and Eta variants of concern in January 2021. The Alpha variant remained dominant throughout early 2021 until the arrival of the Delta variant in July. Surprisingly, despite the small sample size of our study, we also found the persistence of the early SARS-CoV-2 clade 19B as late as April 2021. Together, these data help fill in our understanding of the SARS-CoV-2 population dynamics in West Africa early in the COVID-19 pandemic.

Media Type:

Electronic Article

Year of Publication:

2024

Publication:

2024

Contained In:

To Main Record - volume:19

Contained In:

PloS one - 19(2024), 3 vom: 01., Seite e0299082

Language:

English

Contributors:

Sow, Mamadou Saliou [Author]
Togo, Josue [Author]
Simons, Lacy M [Author]
Diallo, Souleymane Taran [Author]
Magassouba, Mohamed Lamine [Author]
Keita, Mamadou Bhoye [Author]
Somboro, Anou Moise [Author]
Coulibaly, Youssouf [Author]
Ozer, Egon A [Author]
Hultquist, Judd F [Author]
Murphy, Robert Leo [Author]
Maiga, Almoustapha Issiaka [Author]
Maiga, Mamoudou [Author]
Lorenzo-Redondo, Ramon [Author]

Links:

Volltext

Keywords:

Journal Article

Notes:

Date Completed 08.03.2024

Date Revised 18.05.2024

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.1371/journal.pone.0299082

funding:

Supporting institution / Project title:

PPN (Catalogue-ID):

NLM369366336