Boron nanosheets as a phosphatase mimicking nanozyme with ultrahigh catalytic activity for prodrug-based cancer therapy
Boron nanosheets (BNSs) are reported as a new phosphatase mimicking nanozyme. Surprisingly, the catalytic rate of BNSs is up to 17 times those of known phosphatase mimicking nanozymes. By adding polyols and Lewis bases, the catalytic activity of BNSs was attributed to the Lewis acidity of the B centers of the BNSs. Theoretical investigation shows that the B centers are responsible for the catalytic hydrolysis of phosphoesters. Moreover, the biomimetic activity of the BNSs was further explored for enhancing anticancer therapy through nanozyme-catalyzed prodrug conversion.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 60(2024), 26 vom: 26. März, Seite 3523-3526 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lei, Yao [VerfasserIn] |
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| Links: |
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| Themen: |
Boron |
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| Anmerkungen: |
Date Completed 27.03.2024 Date Revised 27.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d3cc05616c |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369360052 |
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| 520 | |a Boron nanosheets (BNSs) are reported as a new phosphatase mimicking nanozyme. Surprisingly, the catalytic rate of BNSs is up to 17 times those of known phosphatase mimicking nanozymes. By adding polyols and Lewis bases, the catalytic activity of BNSs was attributed to the Lewis acidity of the B centers of the BNSs. Theoretical investigation shows that the B centers are responsible for the catalytic hydrolysis of phosphoesters. Moreover, the biomimetic activity of the BNSs was further explored for enhancing anticancer therapy through nanozyme-catalyzed prodrug conversion | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Phosphoric Monoester Hydrolases |2 NLM | |
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| 650 | 7 | |a Boron |2 NLM | |
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| 700 | 1 | |a Zhao, Qianghong |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Zhou |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yusha |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Lianzhe |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Zhining |e verfasserin |4 aut | |
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