Recent developments of agents targeting Vibrio cholerae : patents and literature data
INTRODUCTION: Vibrio cholerae bacteria cause an infection characterized by acute diarrheal illness in the intestine. Cholera is sustained by people swallowing contaminated food or water. Even though symptoms can be mild, if untreated disease becomes severe and life-threatening, especially in low-income countries.
AREAS COVERED: After a description of the most recent literature on the pathophysiology of this infection, we searched for patents and literature articles following the PRISMA guidelines, filtering the results disclosed from 2020 to present. Moreover, some innovative molecular targets (e.g., carbonic anhydrases) and pathways to counteract this rising problem were also discussed in terms of design, structure-activity relationships and structural analyses.
EXPERT OPINION: This review aims to cover and analyze the most recent advances on the new druggable targets and bioactive compounds against this fastidious pathogen, overcoming the use of old antibiotics which currently suffer from high resistance rate.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Expert opinion on therapeutic patents - (2024) vom: 11. März, Seite 1-18 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Melfi, Francesco [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Aspartate-semialdehyde dehydrogenase |
|---|
| Anmerkungen: |
Date Revised 11.03.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1080/13543776.2024.2327305 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369358430 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369358430 | ||
| 003 | DE-627 | ||
| 005 | 20240311232524.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240306s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/13543776.2024.2327305 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1323.xml |
| 035 | |a (DE-627)NLM369358430 | ||
| 035 | |a (NLM)38446009 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Melfi, Francesco |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Recent developments of agents targeting Vibrio cholerae |b patents and literature data |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 11.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a INTRODUCTION: Vibrio cholerae bacteria cause an infection characterized by acute diarrheal illness in the intestine. Cholera is sustained by people swallowing contaminated food or water. Even though symptoms can be mild, if untreated disease becomes severe and life-threatening, especially in low-income countries | ||
| 520 | |a AREAS COVERED: After a description of the most recent literature on the pathophysiology of this infection, we searched for patents and literature articles following the PRISMA guidelines, filtering the results disclosed from 2020 to present. Moreover, some innovative molecular targets (e.g., carbonic anhydrases) and pathways to counteract this rising problem were also discussed in terms of design, structure-activity relationships and structural analyses | ||
| 520 | |a EXPERT OPINION: This review aims to cover and analyze the most recent advances on the new druggable targets and bioactive compounds against this fastidious pathogen, overcoming the use of old antibiotics which currently suffer from high resistance rate | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a IspH | |
| 650 | 4 | |a Vibrio cholerae | |
| 650 | 4 | |a aspartate-semialdehyde dehydrogenase | |
| 650 | 4 | |a biofilm | |
| 650 | 4 | |a carbonic anhydrase | |
| 650 | 4 | |a flagellar regulatory hierarchy | |
| 650 | 4 | |a quorum sensing | |
| 700 | 1 | |a Carradori, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Mencarelli, Noemi |e verfasserin |4 aut | |
| 700 | 1 | |a Campestre, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Granese, Arianna |e verfasserin |4 aut | |
| 700 | 1 | |a Mori, Mattia |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Expert opinion on therapeutic patents |d 1998 |g (2024) vom: 11. März, Seite 1-18 |w (DE-627)NLM094580006 |x 1744-7674 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:11 |g month:03 |g pages:1-18 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/13543776.2024.2327305 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 11 |c 03 |h 1-18 | ||