Real-world walking cadence in people with COPD
Copyright ©The authors 2024..
Introduction: The clinical validity of real-world walking cadence in people with COPD is unsettled. Our objective was to assess the levels, variability and association with clinically relevant COPD characteristics and outcomes of real-world walking cadence.
Methods: We assessed walking cadence (steps per minute during walking bouts longer than 10 s) from 7 days' accelerometer data in 593 individuals with COPD from five European countries, and clinical and functional characteristics from validated questionnaires and standardised tests. Severe exacerbations during a 12-month follow-up were recorded from patient reports and medical registries.
Results: Participants were mostly male (80%) and had mean±sd age of 68±8 years, post-bronchodilator forced expiratory volume in 1 s (FEV1) of 57±19% predicted and walked 6880±3926 steps·day-1. Mean walking cadence was 88±9 steps·min-1, followed a normal distribution and was highly stable within-person (intraclass correlation coefficient 0.92, 95% CI 0.90-0.93). After adjusting for age, sex, height and number of walking bouts in fractional polynomial or linear regressions, walking cadence was positively associated with FEV1, 6-min walk distance, physical activity (steps·day-1, time in moderate-to-vigorous physical activity, vector magnitude units, walking time, intensity during locomotion), physical activity experience and health-related quality of life and negatively associated with breathlessness and depression (all p<0.05). These associations remained after further adjustment for daily steps. In negative binomial regression adjusted for multiple confounders, walking cadence related to lower number of severe exacerbations during follow-up (incidence rate ratio 0.94 per step·min-1, 95% CI 0.91-0.99, p=0.009).
Conclusions: Higher real-world walking cadence is associated with better COPD status and lower severe exacerbations risk, which makes it attractive as a future prognostic marker and clinical outcome.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
ERJ open research - 10(2024), 2 vom: 19. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Delgado-Ortiz, Laura [VerfasserIn] |
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| Anmerkungen: |
Date Revised 07.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1183/23120541.00673-2023 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369344871 |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright ©The authors 2024. | ||
| 520 | |a Introduction: The clinical validity of real-world walking cadence in people with COPD is unsettled. Our objective was to assess the levels, variability and association with clinically relevant COPD characteristics and outcomes of real-world walking cadence | ||
| 520 | |a Methods: We assessed walking cadence (steps per minute during walking bouts longer than 10 s) from 7 days' accelerometer data in 593 individuals with COPD from five European countries, and clinical and functional characteristics from validated questionnaires and standardised tests. Severe exacerbations during a 12-month follow-up were recorded from patient reports and medical registries | ||
| 520 | |a Results: Participants were mostly male (80%) and had mean±sd age of 68±8 years, post-bronchodilator forced expiratory volume in 1 s (FEV1) of 57±19% predicted and walked 6880±3926 steps·day-1. Mean walking cadence was 88±9 steps·min-1, followed a normal distribution and was highly stable within-person (intraclass correlation coefficient 0.92, 95% CI 0.90-0.93). After adjusting for age, sex, height and number of walking bouts in fractional polynomial or linear regressions, walking cadence was positively associated with FEV1, 6-min walk distance, physical activity (steps·day-1, time in moderate-to-vigorous physical activity, vector magnitude units, walking time, intensity during locomotion), physical activity experience and health-related quality of life and negatively associated with breathlessness and depression (all p<0.05). These associations remained after further adjustment for daily steps. In negative binomial regression adjusted for multiple confounders, walking cadence related to lower number of severe exacerbations during follow-up (incidence rate ratio 0.94 per step·min-1, 95% CI 0.91-0.99, p=0.009) | ||
| 520 | |a Conclusions: Higher real-world walking cadence is associated with better COPD status and lower severe exacerbations risk, which makes it attractive as a future prognostic marker and clinical outcome | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Ranciati, Saverio |e verfasserin |4 aut | |
| 700 | 1 | |a Arbillaga-Etxarri, Ane |e verfasserin |4 aut | |
| 700 | 1 | |a Balcells, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Buekers, Joren |e verfasserin |4 aut | |
| 700 | 1 | |a Demeyer, Heleen |e verfasserin |4 aut | |
| 700 | 1 | |a Frei, Anja |e verfasserin |4 aut | |
| 700 | 1 | |a Gimeno-Santos, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Hopkinson, Nicholas S |e verfasserin |4 aut | |
| 700 | 1 | |a de Jong, Corina |e verfasserin |4 aut | |
| 700 | 1 | |a Karlsson, Niklas |e verfasserin |4 aut | |
| 700 | 1 | |a Louvaris, Zafeiris |e verfasserin |4 aut | |
| 700 | 1 | |a Palmerini, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Polkey, Michael I |e verfasserin |4 aut | |
| 700 | 1 | |a Puhan, Milo A |e verfasserin |4 aut | |
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| 700 | 1 | |a Toran-Montserrat, Pere |e verfasserin |4 aut | |
| 700 | 1 | |a Vogiatzis, Ioannis |e verfasserin |4 aut | |
| 700 | 1 | |a Watz, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Troosters, Thierry |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Aymerich, Judith |e verfasserin |4 aut | |
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