IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma
© 2024 The Author(s)..
IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with Cλ1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Leukemia research reports - 21(2024) vom: 15., Seite 100451 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hosoi, Hiroki [VerfasserIn] |
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| Links: |
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| Themen: |
Immunoglobulin lambda like polypeptide 5 (igll5) |
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| Anmerkungen: |
Date Revised 07.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.lrr.2024.100451 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369343484 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024 The Author(s). | ||
| 520 | |a IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with Cλ1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Immunoglobulin lambda like polypeptide 5 (igll5) | |
| 650 | 4 | |a Mature b-cell lymphoma | |
| 650 | 4 | |a Super-enhancer, SiRNA | |
| 700 | 1 | |a Tabata, Shotaro |e verfasserin |4 aut | |
| 700 | 1 | |a Kosako, Hideki |e verfasserin |4 aut | |
| 700 | 1 | |a Hori, Yoshikazu |e verfasserin |4 aut | |
| 700 | 1 | |a Okamura, Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Fujimoto, Kota |e verfasserin |4 aut | |
| 700 | 1 | |a Kajioka, Daiki |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Osato, Motomi |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Gen |e verfasserin |4 aut | |
| 700 | 1 | |a Sonoki, Takashi |e verfasserin |4 aut | |
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